Evidence map›Paper›PMID 33095973›Full record

ArticleJournal of diabetes investigation2021

Effects of passage through the digestive tract on incretin secretion: Before and after birth.

Seiichi Tomotaki, Ryosuke Araki, Kouji Motokura, Yutaro Tomobe, Takeru Yamauchi, Shintaro Hanaoka, Hiroko Tomotaki, Kougoro Iwanaga, Fusako Niwa, Junko Takita and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Seiichi TomotakiDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-7004-6608
Ryosuke ArakiDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kouji MotokuraDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yutaro TomobeDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takeru YamauchiDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shintaro HanaokaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroko TomotakiDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kougoro IwanagaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Fusako NiwaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Junko TakitaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Masahiko KawaiDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kyoto University · JP

Funding

JSPS KAKENHI JP18K17922The Japan Foundation for Pediatric Research 18-010
6 · The paper itself

Abstract

AIMS/

introductionIt was reported that fetuses secrete endogenous incretin; however, the stimulants of fetal incretin secretion are not fully understood. To investigate the association between the passage of amniotic fluid through the intestinal tract and fetal secretion of incretin, we analyzed umbilical cord incretin levels of infants with duodenum atresia. MATERIALS AND

methodsInfants born from July 2017 to July 2019 (infants with duodenum atresia and normal term or preterm infants) were enrolled. We measured and compared the concentrations of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide/glucose-dependent insulinotropic polypeptide (GIP) in the umbilical vein and preprandial blood samples after birth.

resultsA total of 98 infants (47 term, 46 preterm and 5 with duodenum atresia) were included. In patients with duodenum atresia, umbilical vein GLP-1 and GIP levels were the same as those in normal infants. In postnatal samples, there were positive correlations between the amount of enteral feeding and preprandial serum concentrations of GLP-1 (r = 0.47) or GIP (r = 0.49).

conclusionsOur results show that enteral feeding is important for secretion of GLP-1 and GIP in postnatal infants, whereas the passage of amniotic fluid is not important for fetal secretion of GLP-1 and GIP. The effect of ingested material passing through the digestive tract on incretin secretion might change before and after birth. Other factors might stimulate secretion of GLP-1 and GIP during the fetal period.

Indexed as

Duodenal DiseasesEnteral NutritionFemaleGastric Inhibitory PolypeptideGastrointestinal TractGlucagon-Like Peptide 1HumansIncretinsInfant, NewbornInfant, PrematureIntestinal AtresiaIntestinal SecretionsMalePregnancyUmbilical CordGastric Inhibitory PolypeptideGlucagon-Like Peptide 1IncretinsFetusGlucagon-like peptide-1Glucose-dependent insulinotropic polypeptide

Identifiers

PMID33095973
PMCPMC8169361
OpenAlexW3094039498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.