Evidence map›Paper›PMID 33095904›Full record

ArticleJournal of endocrinological investigation2021

Stimulated GH levels during the transition phase in Prader-Willi syndrome.

G Grugni, P Marzullo, M Delvecchio, L Iughetti, M R Licenziati, S Osimani, L Ragusa, A Salvatoni, A Sartorio, S Stagi and 2 more

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In one paragraph

Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study.The Journal of clinical endocrinology and metabolism · 2023
    Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

G GrugniDivision of Auxology, Istituto Auxologico Italiano, S. Giuseppe Hospital, Research Institute, Strada Cadorna 90, 28824, Piancavallo, Verbania, Italy. g.grugni@auxologico.it.ORCID http://orcid.org/0000-0003-4708-2544
P MarzulloDivision of General Medicine, Istituto Auxologico Italiano, S. Giuseppe Hospital, Research Institute, Piancavallo, Verbania, Italy.
M DelvecchioMetabolic Diseases, Clinical Genetics and Diabetology Unit, Giovanni XXIII Children's Hospital, Bari, Italy.
L IughettiPediatric Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
M R LicenziatiDepartment of Neurosciences, Santobono-Pausilipon Children's Hospital, Naples, Italy.
S OsimaniDepartment of Pediatrics, San Raffaele Hospital, Research Institute, Milan, Italy.
L RagusaDepartment of Pediatric Endocrinology, Oasi Maria SS, Research Institute, Troina, Enna, Italy.
A SalvatoniDepartment of Pediatrics, University of Insubria, Varese, Italy.
A SartorioDivision of Auxology, Istituto Auxologico Italiano, S. Giuseppe Hospital, Research Institute, Strada Cadorna 90, 28824, Piancavallo, Verbania, Italy.
S StagiDivision of Pediatric Endocrinology, Meyer University Children's Hospital, Florence, Italy.
A CrinòReference Center for Prader-Willi Syndrome, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.
Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED)
IRCCS Istituto Auxologico Italiano · ITBambino Gesù Children's Hospital · ITMeyer Children's Hospital · ITOasi Maria SS · ITOspedale Pediatrico Giovanni XXIII · ITSan Raffaele University of Rome · ITSantobono Children's Hospital · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Insubria · ITUniversity of Modena and Reggio Emilia · IT

Funding

Ministero della Salute 01C629
6 · The paper itself

Abstract

purposeEarly institution of GH therapy in children with Prader-Willi syndrome (PWS) yields beneficial effects on their phenotype and is associated with a persistent improvement of body composition, both in the transition age and in adulthood. Reports from GH stimulation testing in PWS adults, however, suggest that GH deficiency (GHD) is not a universal feature of the syndrome, and the current Consensus Guidelines suggest to perform a reassessment of persistent GHD so as to continue GH therapy after reaching adult height. Few data about GH responsiveness to stimulation testing throughout the transitional period in PWS are available to date. Thus, we investigated the prevalence of GHD in a large cohort of patients with PWS during the transition phase. PATIENTS AND

methodsOne hundred forty-one PWS patients, 72 females and 69 males, aged 15.4-24.9 years, were evaluated by dynamic testing with growth hormone-releasing hormone (GHRH) plus arginine (GHRH + ARG). To define GHD, both BMI-dependent and BMI-independent diagnostic cut-off limits were considered.

resultsAccording to BMI-dependent criteria, 10.7% of normal weight (NW), 18.5% of overweight and 22.1% of obese PWS maintained a status of GHD. Similar results were obtained by adopting a cut-off limit specific for the adult age (26.2%), as well as criteria for the transition phase in NW subjects (25%).

conclusionOur study shows that about 20% of patients with PWS fulfilled the criteria for GHD during the transitional age, suggesting the need of an integrated analysis of GH/IGF-I axis, in the context of the general clinical picture and other endocrine abnormalities, in all subjects after attainment of final stature.

Indexed as

AdolescentAdultArginineBody CompositionFemaleFollow-Up StudiesGrowth Hormone-Releasing HormoneHuman Growth HormoneHumansInsulin-Like Growth Factor IMaleObesityPrader-Willi SyndromePrognosisRetrospective StudiesYoung AdultArginineGrowth Hormone-Releasing HormoneHuman Growth HormoneIGF1 protein, humanInsulin-Like Growth Factor IGrowth hormoneGrowth hormone deficiencyIGF-IObesityPrader–Willi syndrome

Identifiers

PMID33095904
OpenAlexW3094193335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.