ArticleOmics : a journal of integrative biology2020
Postmortomics: The Potential of Untargeted Metabolomics to Highlight Markers for Time Since Death.
Article in Omics : a journal of integrative biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Advances in postmortem interval estimation: A systematic review of machine learning and metabolomics across various tissue types.Forensic science, medicine, and pathology · 2025Pooled it
- "Omics" and Postmortem Interval Estimation: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Human Decomposition and Time Since Death: Persistent Challenges and Future Directions of Postmortem Interval Estimation in Forensic Anthropology.American journal of biological anthropology · 2024Pooled it
- Lipidomes in Cadaveric Decomposition and Determination of the Postmortem Interval: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Postmortem metabolomics as a window into the agonal phase of death: a comparison between opioid intoxications and hangings.International journal of legal medicine · 2026Article
- Human-to-Rat Validation of PMI Biomarkers: A Bidirectional Cross-Species Metabolomics Study Reveals Asymmetric Translation.Analytical chemistry · 2026Article
- FTIR Spectroscopy of Vitreous Humor for Postmortem Interval Estimation: A Multivariate Regression Approach.International journal of molecular sciences · 2026Article
- The human metabolome and machine learning improves predictions of the post-mortem interval.Nature communications · 2026Article
- Comparative evaluation of metabolomic, microbial, and integrated features for distinguishing a rat model of heatstroke death from cervical-dislocation controls and estimating postmortem interval across organs.Frontiers in microbiology · 2026Article
- Recent Advances in Forensic Medicine at the Horizon of Omics Sciences and New Biomarkers for Postmortem Interval Estimation.Maedica · 2025Review
- Forensic Metabolomics: Enhancing PMI Estimation through Porcine Bone Tissue Profiling.Journal of proteome research · 2025Article
- Estimation of postmortem interval under different ambient temperatures based on multi-organ metabolomics and machine learning algorithm.International journal of legal medicine · 2025Article
- Translating metabolomic evidence gathered from an animal model to a real human scenario: the post-mortem interval issue.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Metabolic Pattern of Brain Death-NMR-Based Metabolomics of Cerebrospinal Fluid.International journal of molecular sciences · 2025Article
- RedefiningFrontiers in microbiology · 2025Review
- UPLC/Q-TOF MS-based femoral muscle metabolomic analysis under high-temperature: a proof of concept for postmortem interval estimation.Frontiers in medicine · 2025Article
- Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.Nature genetics · 2024Article
- Spectroscopic Analysis of Tryptophan as a Potential Optical Biomarker for Estimating the Time of Death.International journal of molecular sciences · 2024Article
- Influence of Drugs and Toxins on Decomposition Dynamics: Forensic Implications.Molecules (Basel, Switzerland) · 2024Review
- Postmortem metabolomics as a high-throughput cause-of-death screening tool for human death investigations.iScience · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The success of forensic investigations involving fatalities very often depends on the establishment of the correct timeline of events. Currently used methods for estimating the postmortem interval (PMI) are mostly dependent on the professional and tacit experience of the investigator, and often with poor reliability in the absence of robust biological markers. The aim of this study was to investigate the potential of metabolomic approaches to highlight molecular markers for PMI. Rat and human muscle tissues, collected at various times postmortem, were analyzed using an untargeted metabolomics approach. Levels of certain metabolites (skatole, xanthine, n-acetylneuraminate, 1-methylnicotinamide, choline phosphate, and uracil) as well as most proteinogenic amino acids increased steadily postmortem. Threonine, tyrosine, and lysine show the most predictable evolution over the postmortem period, and may thus have potential for possible PMI markers in the future. This study demonstrates how a biomarker discovery approach can be extended to forensic investigations using untargeted metabolomics.
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