Evidence map›Paper›PMID 33095402›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020

Treatment of Dystonia: Medications, Neurotoxins, Neuromodulation, and Rehabilitation.

Ian O Bledsoe, Aaron C Viser, Marta San Luciano

Open access · bronzeAbstract readReview
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Dystonia: pathophysiology and the role of acupuncture in treatment.Wiener medizinische Wochenschrift (1946) · 2025
    Review
  6. Magnetic resonance-guided focused ultrasound in dystonia: a scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  7. Article
  8. The Role of Ultrasound in the Evaluation of Tardive Dyskinesia: A Case Series.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Basis of movement control in dystonia and why botulinum toxin should influence it?Toxicon : official journal of the International Society on Toxinology · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ian O BledsoeWeill Institute for Neurosciences, Movement Disorder and Neuromodulation Center, University of California, San Francisco, 1635 Divisadero St., Suite 520, San Francisco, CA, 94115, USA. Ian.Bledsoe@ucsf.edu.ORCID http://orcid.org/0000-0001-8885-8148
Aaron C ViserWeill Institute for Neurosciences, Movement Disorder and Neuromodulation Center, University of California, San Francisco, 1635 Divisadero St., Suite 520, San Francisco, CA, 94115, USA.
Marta San LucianoWeill Institute for Neurosciences, Movement Disorder and Neuromodulation Center, University of California, San Francisco, 1635 Divisadero St., Suite 520, San Francisco, CA, 94115, USA.
University of California, San Francisco · US

Funding

Cerebellar deep brain stimulation for severe combined movement disorders and spasticity in children and young adults with cerebral palsyUH3NS128297 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Marta San Luciano · 2024 to 2026
$3.1M
Optimizing Phenogenotypic and Neuromodulation Predictors in Deep BrainStimulation Surgery for Isolated DystoniaK23NS099441 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAN LUCIANO, MARTA · 2017 to 2021
$1000k
NINDS NIH HHS K23 NS099441NINDS NIH HHS UH3 NS128297
6 · The paper itself

Abstract

Dystonia is a complex disorder with numerous presentations occurring in isolation or in combination with other neurologic symptoms. Its treatment has been significantly improved with the advent of botulinum toxin and deep brain stimulation in recent years, though additional investigation is needed to further refine these interventions. Medications are of critical importance in forms of dopa-responsive dystonia but can be beneficial in other forms of dystonia as well. Many different rehabilitative paradigms have been studied with variable benefit. There is growing interest in noninvasive stimulation as a potential treatment, but with limited long-term benefit shown to date, and additional research is needed. This article reviews existing evidence for treatments from each of these categories. To date, there are many examples of incomplete response to available treatments, and improved therapies are needed.

Indexed as

Botulinum ToxinsDeep Brain StimulationDopamine AgentsDystoniaHumansNeurotoxinsTranscutaneous Electric Nerve StimulationTreatment OutcomeBotulinum ToxinsDopamine AgentsNeurotoxinsbotulinum toxindeep brain stimulationDystonianeuromodulationrehabilitation

Identifiers

PMID33095402
PMCPMC7851280
OpenAlexW3093603348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.