Evidence map›Paper›PMID 33095298›Full record

ArticlePflugers Archiv : European journal of physiology2020

Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking.

Nadine Erlenhardt, Olaf Kletke, Franziska Wohlfarth, Marlene A Komadowski, Lukas Clasen, Hisaki Makimoto, Susanne Rinné, Malte Kelm, Christiane Jungen, Niels Decher and 2 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The Dysfunction of CaInternational journal of molecular sciences · 2023
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Nadine ErlenhardtInstitute of Neurophysiology, Medical Faculty, University of Düsseldorf, Universitätsstr 1, 40225, Düsseldorf, Germany.
Olaf KletkeInstitute of Neurophysiology, Medical Faculty, University of Düsseldorf, Universitätsstr 1, 40225, Düsseldorf, Germany.
Franziska WohlfarthInstitute of Neurophysiology, Medical Faculty, University of Düsseldorf, Universitätsstr 1, 40225, Düsseldorf, Germany.
Marlene A KomadowskiInstitute of Physiology and Pathophysiology and Marburg Center for Mind, Brain, and Behavior, Philipps-University Marburg, Deutschhausstrasse 1-2, 35037, Marburg, Germany.
Lukas ClasenDepartment of Cardiology Pulmonology and Vascular Medicine Medical Faculty, University Hospital Düsseldorf, Moorenstr 5, 40225, Düsseldorf, Germany.
Hisaki MakimotoDepartment of Cardiology Pulmonology and Vascular Medicine Medical Faculty, University Hospital Düsseldorf, Moorenstr 5, 40225, Düsseldorf, Germany.
Susanne RinnéInstitute of Physiology and Pathophysiology and Marburg Center for Mind, Brain, and Behavior, Philipps-University Marburg, Deutschhausstrasse 1-2, 35037, Marburg, Germany.
Malte KelmDepartment of Cardiology Pulmonology and Vascular Medicine Medical Faculty, University Hospital Düsseldorf, Moorenstr 5, 40225, Düsseldorf, Germany.
Christiane JungenDepartment of Cardiology, University Heart Center, University Hospital Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany.
Niels DecherInstitute of Physiology and Pathophysiology and Marburg Center for Mind, Brain, and Behavior, Philipps-University Marburg, Deutschhausstrasse 1-2, 35037, Marburg, Germany.
Christian MeyerInstitute of Neurophysiology, Medical Faculty, University of Düsseldorf, Universitätsstr 1, 40225, Düsseldorf, Germany.
Nikolaj KlöckerInstitute of Neurophysiology, Medical Faculty, University of Düsseldorf, Universitätsstr 1, 40225, Düsseldorf, Germany. nikolaj.kloecker@uni-duesseldorf.de.ORCID http://orcid.org/0000-0002-7864-1348
Düsseldorf University Hospital · DEPhilipps University of Marburg · DEHeinrich Heine University Düsseldorf · DEUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hyperpolarization-activated cation current I

Indexed as

Heart RateMutation, MissenseAction PotentialsAnimalsBradycardiaCells, CulturedFemaleHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMiddle AgedMuscle ProteinsMyocytes, CardiacPotassium ChannelsProtein TransportRatsRats, WistarHCN4 protein, humanHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMuscle ProteinsPotassium ChannelsFunny currentGenetic variantHCN channelPEX5RSick sinus syndromeTrip8b

Identifiers

PMID33095298
PMCPMC7691308
OpenAlexW3094545751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.