SynthesisHerz2021
Genetic association between eNOS gene polymorphisms and risk of carotid atherosclerosis : A meta-analysis.
Synthesis in Herz, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- A systematic review and network meta-analysis of single nucleotide polymorphisms associated with oral submucous fibrosis risk.Medicine · 2026Pooled it
- Pooled it
- Associations of Polymorphic Variants of the eNOS Gene with Cardiovascular Risk Factors in Patients with Carbohydrate Metabolism Disorders.Bulletin of experimental biology and medicine · 2026Observational
- Golgi-Targeted Viscosity Fluorescent Probe for Monitoring Acute Lung Injury.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Hemodynamic effects of pulsatile frequency of right ventricular assist device (RVAD) on pulmonary perfusion: a simulation study.Medical & biological engineering & computing · 2024Article
- Advancing forensic-based investigation incorporating slime mould search for gene selection of high-dimensional genetic data.Scientific reports · 2024Article
- Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy.Current gene therapy · 2024Review
- Bioinformatics, expression analysis, and functional verification of allene oxide synthase geneOpen life sciences · 2024Article
- Usage of computational method for hemodynamic analysis of intracranial aneurysm rupture risk in different geometrical aspects.Scientific reports · 2023Article
- Influence of parent vessel feature on the risk of internal carotid artery aneurysm rupture via computational method.Scientific reports · 2023Article
- Computational and statistical analyses of blood hemodynamic inside cerebral aneurysms for treatment evaluation of endovascular coiling.Scientific reports · 2023Article
- Endocrine and metabolic factors and the risk of idiopathic pulmonary fibrosis: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Investigation of eNOS G894T Gene Polymorphism in Patients with Pseudoexfoliation Syndrome: A Preliminary Study.Beyoglu eye journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndothelial nitric oxide synthase (eNOS) has been reported to be involved in the atherosclerotic process. A number of studies have investigated the association between eNOS gene polymorphisms and the risk of carotid atherosclerosis (CAS). However, the results are conflicting and inconclusive. The aim of this study was to evaluate precisely the association between the eNOS T786C, G894T, and 4a/4b polymorphisms and CAS risk. MATERIAL AND
methodsA meta-analysis was carried out by retrieving relevant studies from PubMed, Embase, China National Knowledge Infrastructure (CNKI), and Cochrane databases without a restriction on publication year. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to describe the strength of the association with CAS.
resultsData were obtained from eight case-control studies comprising 2975 cases and 2624 controls. Significant associations were detected between the allelic and recessive models of the eNOS T786C polymorphism (allelic: p = 0.04; OR, 95% CI = 1.57 [1.01, 2.44]; recessive: p = 0.03; OR, 95% CI = 1.53 [1.04, 2.24]), as well as the allelic and dominant models of the eNOS 4a/4b polymorphism, and CAS risk in an Asian subgroup (allelic: p = 0.02; OR, 95% CI = 1.49 [1.07, 2.07]; dominant: p = 0.01; OR, 95% CI = 1.50 [1.09, 2.05]), but not in a Caucasian subgroup (p > 0.05). No association was observed between the eNOS G894T polymorphism and CAS risk (p > 0.05).
conclusionOur study provides evidence that the allelic and recessive models of the eNOS T786C polymorphism and the allelic and dominant models of the eNOS 4a/4b polymorphism may increase the risk of CAS in Asian populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.