ArticleGenome biology and evolution2020
Mitochondrial DNA Sequence Diversity in Mammals: A Correlation between the Effective and Census Population Sizes.
Article in Genome biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Transition-Transversion Bias at theEcology and evolution · 2026Article
- Levels of additive genetic variation vary substantially between species.PLoS biology · 2026Article
- Mitochondrial diversity of Bwindi Impenetrable National Park Mountain Gorillas.Genome biology · 2025Article
- Drivers of genetic diversity across the marine tree of life.bioRxiv : the preprint server for biology · 2025Article
- Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes.Biogerontology · 2024Review
- Genomic Diversity as a Key Conservation Criterion: Proof-of-Concept From Mammalian Whole-Genome Resequencing Data.Evolutionary applications · 2024Article
- Exploring the genetic diversity of genotypes G8 and G10 of theParasitology · 2023Article
- What Determines Levels of Mitochondrial Genetic Diversity in Birds?Genome biology and evolution · 2023Article
- Museum specimens of a landlocked pinniped reveal recent loss of genetic diversity and unexpected population connections.Ecology and evolution · 2023Article
- A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size.Genome biology and evolution · 2022Article
- Genetic Diversity, Heteroplasmy, and Recombination in Mitochondrial Genomes of Daphnia pulex, Daphnia pulicaria, and Daphnia obtusa.Molecular biology and evolution · 2022Article
- Rates of Protein Evolution across the Marsupial Phylogeny: Heterogeneity and Link to Life-History Traits.Genome biology and evolution · 2022Article
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2 authors.
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Abstract
What determines the level of genetic diversity of a species remains one of the enduring problems of population genetics. Because neutral diversity depends upon the product of the effective population size and mutation rate, there is an expectation that diversity should be correlated to measures of census population size. This correlation is often observed for nuclear but not for mitochondrial DNA. Here, we revisit the question of whether mitochondrial DNA sequence diversity is correlated to census population size by compiling the largest data set to date, using 639 mammalian species. In a multiple regression, we find that nucleotide diversity is significantly correlated to both range size and mass-specific metabolic rate, but not a variety of other factors. We also find that a measure of the effective population size, the ratio of nonsynonymous to synonymous diversity, is also significantly negatively correlated to both range size and mass-specific metabolic rate. These results together suggest that species with larger ranges have larger effective population sizes. The slope of the relationship between diversity and range is such that doubling the range increases diversity by 12-20%, providing one of the first quantifications of the relationship between diversity and the census population size.
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