ArticleHuman brain mapping2021
Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Exploring the Autistic Brain: A Systematic Review of Diffusion Tensor Imaging Studies on Neural Connectivity in Autism Spectrum Disorder.Brain sciences · 2025Review
- Layer-Dependent Effect of Aβ-Pathology on Cortical Microstructure With Ex Vivo Human Brain Diffusion MRI at 7 Tesla.Human brain mapping · 2025Article
- Article
- Alterations in the white matter fiber tracts of preschool-aged children with autism spectrum disorder: an automated fiber quantification study.Quantitative imaging in medicine and surgery · 2024Article
- Short fiber bundle filtering and test-retest reproducibility of the Superficial White Matter.Frontiers in neuroscience · 2024Article
- Imaging of the superficial white matter in health and disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Tract- and gray matter- based spatial statistics show white matter and gray matter microstructural differences in autistic males.Frontiers in neuroscience · 2023Article
- Multi-tensor diffusion abnormalities of gray matter in an animal model of cortical dysplasia.Frontiers in neurology · 2023Article
- Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging.Frontiers in neurology · 2023Article
- Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood.Human brain mapping · 2021Article
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Authors and funding
19 authors.
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Abstract
Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more recently in vivo neuroimaging studies converge in suggesting that neuroanatomical abnormalities, specifically around the gray-white matter (GWM) boundary, represent a crucial feature of ASD. However, no research has yet characterized the GWM boundary in ASD based on measures of diffusion. Here, we registered diffusion tensor imaging data to the structural T1-weighted images of 92 adults with ASD and 92 matched neurotypical controls in order to examine between-group differences and group-by-sex interactions in fractional anisotropy and mean diffusivity sampled at the GWM boundary, and at different sampling depths within the superficial white and into the gray matter. As hypothesized, we observed atypical diffusion at and around the GWM boundary in ASD, with between-group differences and group-by-sex interactions depending on tissue class and sampling depth. Furthermore, we identified that altered diffusion at the GWM boundary partially (i.e., ~50%) overlapped with atypical gray-white matter tissue contrast in ASD. Our study thus replicates and extends previous work highlighting the GWM boundary as a crucial target of neuropathology in ASD, and guides future work elucidating etiological mechanisms.
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