ArticleNeurogastroenterology and motility2021
Esophagogastric junction morphology and contractile integral on high-resolution manometry in asymptomatic healthy volunteers: An international multicenter study.
Article in Neurogastroenterology and motility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Reduced esophagogastric junction contractile integral in patients with ineffective esophageal motility.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Mean Basal Esophagogastric Junction Pressure Is a Better High-resolution Manometry Predictor of Gastroesophageal Reflux Disease Than Esophagogastric Junction Contractile Integral.Journal of neurogastroenterology and motility · 2026Article
- Pathophysiology of Gastroesophageal Reflux Disease.Digestion · 2026Review
- Esophageal high-resolution manometry and 24 h pH-impedance monitoring normative values in patients with obesity candidate for bariatric and metabolic surgery.Updates in surgery · 2025Article
- Utilizing Esophageal Motility Tests in Diagnosing and Evaluating Gastroesophageal Reflux Disease.Diagnostics (Basel, Switzerland) · 2024Review
- Normative esophagogastric junction contractile integral for healthy Indian volunteers using water perfusion manometry system.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- Novel Diagnostic Techniques in the Evaluation of Gastroesophageal Reflux Disease (GERD).Digestive diseases and sciences · 2023Review
- Ineffective esophageal motility in Chicago Classification version 4.0 better predicts abnormal acid exposure.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Reference high-resolution manometry values after magnetic sphincter augmentation.Neurogastroenterology and motility · 2021Article
- Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0Neurogastroenterology and motility · 2021Review
Corrections and comments
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Authors and funding
26 authors at 20 institutions in 17 countries.
Funding
Abstract
backgroundEsophagogastric junction contractile integral (EGJ-CI) and EGJ morphology are high-resolution manometry (HRM) metrics that assess EGJ barrier function. Normative data standardized across world regions and HRM manufacturers are limited.
methodsOur aim was to determine normative EGJ metrics in a large international cohort of healthy volunteers undergoing HRM (Medtronic, Laborie, and Diversatek software) acquired from 16 countries in four world regions. EGJ-CI was calculated by the same two investigators using a distal contractile integral-like measurement across the EGJ for three respiratory cycles and corrected for respiration (mm Hg cm), using manufacturer-specific software tools. EGJ morphology was designated according to Chicago Classification v3.0. Median EGJ-CI values were calculated across age, genders, HRM systems, and regions.
resultsOf 484 studies (28.0 years, 56.2% F, 60.7% Medtronic studies, 26.0% Laborie, and 13.2% Diversatek), EGJ morphology was type 1 in 97.1%. Median EGJ-CI was similar between Medtronic (37.0 mm Hg cm, IQR 23.6-53.7 mm Hg cm) and Diversatek (34.9 mm Hg cm, IQR 22.1-56.1 mm Hg cm, P = 0.87), but was significantly higher using Laborie equipment (56.5 mm Hg cm, IQR 35.0-75.3 mm Hg cm, P < 0.001). 5
conclusionsEGJ morphology is predominantly type 1 in healthy adults. EGJ-CI varies widely in health, with significant gender influence, but is consistent within each HRM system. Manufacturer-specific normative values should be utilized for clinical HRM interpretation.
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