Evidence map›Paper›PMID 33094829›Full record

ArticleTranslational stroke research2021

Intra-hematomal White Matter Tracts Act As a Scaffold for Macrophage Infiltration After Intracerebral Hemorrhage.

Jingyin Chen, Sravanthi Koduri, Shuhui Dai, Yasunori Toyota, Ya Hua, Neeraj Chaudhary, Aditya S Pandey, Richard F Keep, Guohua Xi

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01829386 (Non-Heme Iron Load Quantification in the Brain on MRI in Patients With Hemorrhagic Stroke), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01829386 completednot on this map

Non-Heme Iron Load Quantification in the Brain on MRI in Patients With Hemorrhagic Stroke

TypeobservationalSponsorUniversity of MichiganRan2013 to 2022Enrolled34ConditionsStrokeArmsMRI scans with non heme iron levels
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Animal models for the study of intracranial hematomas (Review).Experimental and therapeutic medicine · 2023
    Review
  11. Article
  12. The Fate of Erythrocytes after Cerebral Hemorrhage.Translational stroke research · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Jingyin ChenDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Sravanthi KoduriDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Shuhui DaiDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Yasunori ToyotaDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Ya HuaDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Neeraj ChaudharyDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Aditya S PandeyDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Guohua XiDepartment of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA. guohuaxi@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Experimental Cerebral Hemorrhage: Mechanisms and TherapiesR35NS116786 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2020 to 2024
$5.2M
Novel Ultrasonic Technique for the Treatment of Hemorrhagic StrokeR01NS108042 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PANDEY, ADITYA S · 2018 to 2022
$2.6M
Early hematoma lysis and hemoglobin toxicity in intracerebral hemorrhageR01NS106746 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEP, RICHARD F · 2018 to 2022
$2.5M
Iron, minocycline and brain injury after intracerebral hemorrhageR01NS090925 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2015 to 2019
$1.7M
Targeting CD47 to aid in clearing intracerebral hemorrhagesR01NS096917 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA, XI, GUOHUA · 2016 to 2020
$1.7M
Phenomenon of Ultra-Early Erythrolysis in Intracranial Hemorrhage in Humans on MRIR21NS104663 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHAUDHARY, NEERAJ, PANDEY, ADITYA S · 2018 to 2019
$429k
Peroxiredoxin-2 and Intracerebral Hemorrhage-Induced Brain InjuryR21NS112394 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2019 to 2019
$429k
Brain Iron Quantification Based on MRI in Intracerebral HemorrhageR21NS099684 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHAUDHARY, NEERAJ · 2017 to 2018
$426k
NINDS NIH HHS NS116786NINDS NIH HHS R01 NS090925NINDS NIH HHS R01 NS096917NINDS NIH HHS R01 NS106746NINDS NIH HHS R01 NS108042NINDS NIH HHS R21 NS099684NINDS NIH HHS R21 NS104663NINDS NIH HHS R21 NS112394NINDS NIH HHS R35 NS116786
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a stroke subtype with high mortality and severe morbidity. Hemorrhages frequently develop within the white matter, but whether white matter fibers within the hematoma survive after ICH has not been well studied. The current study examines whether white matter fibers persist in the hematoma after ICH, fibers that might be impacted by evacuation, and their relationship to macrophage infiltration in a porcine model. Male piglets had 2.5 ml blood with or without CD47 blocking antibody injected into the right frontal lobe. Brains were harvested from 3 days to 2 months after ICH for brain histology. White matter fibers were detected within the hematoma 3 and 7 days after hemorrhage by brain histology and myelin basic protein immunohistochemistry. White matter still remained in the hematoma cavity at 2 months after ICH. Macrophage scavenger receptor-1 positive macrophages/microglia and heme oxygenase-1 positive cells infiltrated into the hematoma along the intra-hematomal white matter fibers at 3 and 7 days after ICH. Treatment with CD47 blocking antibody enhanced the infiltration of these cells. In conclusion, white matter fibers exist within the hematoma after ICH and macrophages/microglia may use such fibers as a scaffold to infiltrate into the hematoma and aid in hematoma clearance.

Indexed as

White MatterAnimalsCerebral HemorrhageHematomaMacrophagesMaleMicrogliaSwineIntracerebral hemorrhageMicroglia/macrophagesPhagocytosisWhite matter

Identifiers

PMID33094829
PMCPMC8060356
OpenAlexW3094571691

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.