Adverse effects on cognition caused by combined low vitamin B-12 and high folate status-we must do better than a definite maybe!

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

1. Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial.The Journal of nutrition · 2021
   Trial
2. Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025
   Review
3. Excess Folic Acid Exposure Increases Uracil Misincorporation into DNA in a Tissue-Specific Manner in a Mouse Model of Reduced Methionine Synthase Expression.The Journal of nutrition · 2024
   Article
4. Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023
   Article
5. Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity.PNAS nexus · 2023
   Article
6. Low vitamin B-12-high folate status in adolescents and pregnant women may have deleterious effects on health of the offspring.The American journal of clinical nutrition · 2021
   Article
7. The Effect and Mechanism of Cholesterol and Vitamin BFrontiers in aging neuroscience · 2021
   Article

Corrections and comments

• Commented on by
  Low vitamin B-12-high folate status in adolescents and pregnant women may have deleterious effects on health of the offspring.2021
• Comment on
  High folic acid or folate combined with low vitamin B-12 status: potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES.2020

Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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