ArticleThe Journal of antimicrobial chemotherapy2021
First international quality control programme for laboratories measuring antimicrobial drugs to support dose individualization in critically ill patients.
Article in The Journal of antimicrobial chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Ten-year results of an international external quality control programme for measurement of anti-tuberculosis drug concentrations.The Journal of antimicrobial chemotherapy · 2024Article
- Influence of ultrafiltration conditions on the measurement of unbound drug concentrations: flucloxacillin as an example.The Journal of antimicrobial chemotherapy · 2024Article
- Development and validation of an UPLC-MS/MS assay for the simultaneous quantification of seven commonly used antibiotics in human plasma and its application in therapeutic drug monitoring.The Journal of antimicrobial chemotherapy · 2024Article
- Meropenem Stability in Human Plasma at -20 °C: Detailed Assessment of Degradation.Antibiotics (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors.
Funding
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Abstract
objectivesInternational quality control (proficiency testing) programmes are instituted to safeguard the analytical performance of laboratories and to aid these laboratories in identifying sources of error in their analytical methods. We describe the first international quality control programme for antimicrobial agents that are frequently used in critically ill patients.
methodsSpiked plasma samples with ceftazidime, ciprofloxacin, flucloxacillin, piperacillin, sulfamethoxazole, N-acetyl sulfamethoxazole and trimethoprim were shipped to 22 laboratories from eight different countries. Acceptable accuracy by the performing laboratory was defined if measurements were within 80%-120% limits of the true weighed-in concentrations.
resultsA total of 81% of the measurements (ranging between 56% and 100%, dependent on drug) were within the 80%-120% limits of the true weighed-in concentrations.
conclusionsWe found a relatively good performance of the participating laboratories in measuring eight different antimicrobial drugs. Nevertheless, some of the antimicrobial drugs were not measured properly as up to 44% of the measurements was inaccurate depending on the drug. Our results emphasize the need for and utility of an ongoing quality control programme.
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