Evidence map›Paper›PMID 33094717›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2020

SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.

Sheila F Lumley, David W Eyre, Anna L McNaughton, Alison Howarth, Sarah Hoosdally, Stephanie B Hatch, James Kavanagh, Kevin K Chau, Louise O Downs, Stuart Cox and 26 more

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. COVID-19 and pregnancy: A comparison of case reports, case series and registry studies.European journal of obstetrics, gynecology, and reproductive biology · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Sheila F LumleyNuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
David W EyreNuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
Anna L McNaughtonNuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
Alison HowarthNuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Sarah HoosdallyNuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Stephanie B HatchTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Big Data Institute, Old Road Campus, Oxford, United Kingdom.
James KavanaghNuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Kevin K ChauNuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Louise O DownsDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Stuart CoxDepartment of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Laura DunnDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Anita JusticeDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Susan WareingDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Kate DingleNuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Justine RudkinNuffield Department of Population Health, University of Oxford, Big Data Institute, Old Road Campus, Oxford, United Kingdom.
Kathryn AucklandNuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Alexander FyfeDepartment of Zoology, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
Jai BoltonDepartment of Zoology, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
Robert PatonDepartment of Zoology, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
Alexander J MentzerDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Katie JefferyDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Monique I AnderssonDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Tim JamesDepartment of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Tim E A PetoDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Brian D MarsdenStructural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, United Kingdom.
Gavin ScreatonWellcome Centre for Human Genetics, Nuffield Department of Medicine, Roosevelt Drive, Headington, Oxford, United Kingdom.
Richard J CornallWellcome Centre for Human Genetics, Nuffield Department of Medicine, Roosevelt Drive, Headington, Oxford, United Kingdom.
Paul KlenermanNuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
Daniel EbnerTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Big Data Institute, Old Road Campus, Oxford, United Kingdom.
David I StuartStructural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, United Kingdom.
Derrick W CrookDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Nicole StoesserDepartment of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Stephen H KennedyNuffield Department of Women's & Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Craig ThompsonDepartment of Zoology, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
Sunetra GuptaDepartment of Zoology, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
Philippa C MatthewsNuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.

Funding

Medical Research Council G1100525Medical Research Council MC_UU_00008/6Medical Research Council MR/N00065X/1Medical Research Council MR/V001329/1MRF_ MRF-145-0004-TPG-AVISOWellcome Trust 109965/Z/15/Z
6 · The paper itself

Abstract

SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.

Indexed as

PandemicsPopulation SurveillanceAdolescentAdultAntibodies, NeutralizingAntibodies, ViralBetacoronavirusCohort StudiesCoronavirus InfectionsCOVID-19EnglandEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GMiddle AgedAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GantenatalantibodyCOVID-19ELISAepidemiologyIgGneutralisationpregnancyprevalenceserology

Identifiers

PMID33094717
PMCPMC7651878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.