Evidence map›Paper›PMID 33094663›Full record

ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS

Endothelial prostaglandin D

L Li, E Y Lai, X Cao, W J Welch, C S Wilcox

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the renin-angiotensin-aldosterone system : JRAAS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

L LiHypertension Center and Division of Nephrology and Hypertension, Georgetown University, Washington DC, USA.
E Y LaiHypertension Center and Division of Nephrology and Hypertension, Georgetown University, Washington DC, USA.
X CaoKidney Disease Center, the First Affiliated Hospital and Department of Physiology, School of Basic Medical Science, Zhejiang University School of Medicine, Hangzhou, China.
W J WelchHypertension Center and Division of Nephrology and Hypertension, Georgetown University, Washington DC, USA.
C S WilcoxHypertension Center and Division of Nephrology and Hypertension, Georgetown University, Washington DC, USA.ORCID https://orcid.org/0000-0003-0943-1037
Georgetown University · USZhejiang University · CN

Funding

Renal Vascular Oxidative Stress in HypertensionP01HL068686 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A., SANDBERG, KATHRYN L · 2001 to 2017
$28.8M
Regulation of Renal Function and BP by ThromboxaneR01DK109272 · NIDDK · GEORGETOWN UNIVERSITY · PI WELCH, WILLIAM J, WILCOX, CHRISTOPHER S · 2016 to 2019
$1.4M
NHLBI NIH HHS P01 HL068686NIDDK NIH HHS R01 DK109272
6 · The paper itself

Abstract

hypothesisA lack of contraction of cerebral microarterioles to Ang II ("resilience") depends on cyclooxygenase (COX) and lipocalin type prostaglandin D sythase L-PGDS producing PGD MATERIALS &

methodsContractions were assessed in isolated, perfused vessels and NO by fluorescence microscopy.

resultsThe mRNAs of penetrating intraparenchymal cerebral microarterioles versus renal afferent arterioles were >3000-fold greater for L-PGDS and DP1R and 5-fold for NOS III and COX 2. Larger cerebral arteries contracted with Ang II. However, cerebral microarterioles were entirely unresponsive but contracted with endothelin 1 and perfusion pressure. Ang II contractions were evoked in cerebral microarterioles from COX1 -/- mice or after blockade of COX2, L-PGDS or NOS and in deendothelialized vessels but effects of deendothelialization were lost during COX blockade. NO generation with Ang II depended on COX and also was increased by DP1R activation.

conclusionThe resilience of cerebral arterioles to Ang II contractions is specific for intraparenchymal microarterioles and depends on endothelial COX1 and two products that are metabolized by L-PGDS to generate PGD

Indexed as

PerfusionVasoconstrictionAngiotensin IIAnimalsArteriolesCells, CulturedCyclooxygenase 1Cyclooxygenase 2Endothelial CellsEndothelium, VascularFemaleGene Expression RegulationMaleMice, Inbred C57BLMice, KnockoutMicrovesselsAngiotensin IICyclooxygenase 1Cyclooxygenase 2NG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseProstaglandin D2Prostaglandin-Endoperoxide SynthasesReactive Oxygen SpeciesReceptors, AngiotensinReceptors, ProstaglandincerebrovasculaturecyclooxygenaseLipocalin type prostaglandin Dprostaglandin D2prostaglandin D receptorrenal afferent arteriole

Identifiers

PMID33094663
PMCPMC7585895
OpenAlexW3093989940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.