ReviewPhysiological research2020
Insights into the physiology of C-peptide.
Review in Physiological research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- The dietary calcium-to-magnesium ratio and its association with glycemic control in type 2 diabetes: a cross-sectional study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.Journal of cachexia, sarcopenia and muscle · 2025Article
- Correlation between C-peptide and diabetic retinopathy in patients with type 2 diabetes mellitus: a cross-sectional study.Scientific reports · 2025Article
- Prenatal Ultrasonographic Markers of Macrossomia and C-Peptide in Gestational Diabetes Mellitus: A Prospective Cohort Study.Diagnostics (Basel, Switzerland) · 2025Article
- Computational Spectroscopy Studies of Model Ternary Complexes of Copper(II), C-Peptide, and Serum Albumin Using Excited State-Targeted Geometry Optimization.Biochemistry · 2025Article
- Fasting plasma C-peptide correlates with body mass index, hsCRP, apolipoprotein B, and other atherogenic lipids in healthy individuals.Physiological reports · 2025Article
- A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells.Medical review (2021) · 2025Review
- Copper Deficiency Associated with Glycemic Control in Individuals with Type 2 Diabetes Mellitus.Biological trace element research · 2025Observational
- C-peptide and epicardial adipose tissue in dialysis-dependent chronic kidney disease patients.Frontiers in medicine · 2025Article
- Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon Release in Diabetes Mellitus.International journal of molecular sciences · 2024Article
- Unmet needs in the treatment of type 1 diabetes: why is it so difficult to achieve an improvement in metabolic control?Nutrition & diabetes · 2024Review
- Future clinical prospects of C-peptide testing in the early diagnosis of gestational diabetes.World journal of experimental medicine · 2024Review
- Comparison of customized vacuum sealing drainage and vacuum sealing drainage in the treatment of diabetic foot ulcers: a retrospective analysis.Journal of orthopaedic surgery and research · 2023Article
- Molecular Mechanisms for the Vicious Cycle between Insulin Resistance and the Inflammatory Response in Obesity.International journal of molecular sciences · 2023Review
- Valproate-Induced Metabolic Syndrome.Biomedicines · 2023Review
- The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study.BMC endocrine disorders · 2023Article
- A General Strategy to Install Amidine Functional Groups Along the Peptide Backbone.Journal of the American Chemical Society · 2022Article
- The bidirectional association of C-peptide with cardiovascular risk in nondiabetic adults and patients with newly diagnosed type 2 diabetes mellitus: a retrospective cohort study.Cardiovascular diabetology · 2022Article
- Biomarkers of Glucose Metabolism Alterations and the Onset of Metabolic Syndrome in Survivors of Childhood Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2022Article
- Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current knowledge suggests a complex role of C-peptide in human physiology, but its mechanism of action is only partially understood. The effects of C-peptide appear to be variable depending on the target tissue, physiological environment, its combination with other bioactive molecules such as insulin, or depending on its concentration. It is apparent that C-peptide has therapeutic potential for the treatment of vascular and nervous damage caused by type 1 or late type 2 diabetes mellitus. The question remains whether the effect is mediated by the receptor, the existence of which is still uncertain, or whether an alternative non-receptor-mediated mechanism is responsible. The Institute of Endocrinology in Prague has been paying much attention to the issue of C-peptide and its metabolic effect since the 1980s. The RIA methodology of human C-peptide determination was introduced here and transferred to commercial production. By long-term monitoring of C-peptide oGTT-derived indices, the Institute has contributed to elucidating the pathophysiology of glucose tolerance disorders. This review summarizes the current knowledge of C-peptide physiology and highlights the contributions of the Institute of Endocrinology to this issue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.