SynthesisDevelopmental medicine and child neurology2021
Antenatal diagnosis of fetal intraventricular hemorrhage: systematic review and meta-analysis.
Synthesis in Developmental medicine and child neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Neonatal neurocritical care considerations for prenatally identified neurological disorders.Pediatric research · 2026Review
- Deep learning for intracranial hemorrhage detection and classification in brain CT scans: a systematic review and hybrid model approach.Frontiers in digital health · 2026Review
- Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography.Developmental medicine and child neurology · 2025Review
- Fetal intracerebral hemorrhage: review of the literature and practice considerations.Pediatric research · 2025Review
- Neurodevelopmental outcome of perinatal intracranial haemorrhage in patients born at term: A prospective study.Developmental medicine and child neurology · 2025Observational
- Fetal malformations of cortical development: review and clinical guidance.Brain : a journal of neurology · 2025Review
- Impact of Neighborhood Disadvantage on Gastrointestinal Morbidity in Extremely Low Birthweight Infants.Cureus · 2025Article
- Cerebellar hemorrhage with germinal matrix intraventricular hemorrhage: Continuum from fetal to neonatal life.Developmental medicine and child neurology · 2025Article
- Fetal Cytomegalovirus Associated Intraventricular Hemorrhage: A Rare Prenatal Complication.AJP reports · 2025Article
- Cerebral palsy characteristics in term-born children with and without detectable perinatal risk factors: A cross-sectional study.Developmental medicine and child neurology · 2025Article
- Fetal Intraparenchymal Hemorrhage Imaging Patterns, Etiology, and Outcomes: A Single Center Cohort Study.Annals of neurology · 2024Article
- Fetal intracranial hemorrhage and infarct: Main sonographic and MRI characteristics: A review article.European journal of obstetrics & gynecology and reproductive biology: X · 2024Review
- Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage: a single-center experience.Obstetrics & gynecology science · 2024Article
- Treatment of preterm brain injury via gut-microbiota-metabolite-brain axis.CNS neuroscience & therapeutics · 2024Review
- Review
- High Prevalence of Collagenopathies in Preterm- and Term-Born Children With Periventricular Venous Hemorrhagic Infarction.Journal of child neurology · 2023Article
- Retinal Findings in Haemorrhagic Destruction of the Brain, Subependymal Calcification, and Congenital Cataracts (HDBSCC): Case Report and Review.Neuro-ophthalmology (Aeolus Press) · 2023Article
- Risk Factors for Term-Born Periventricular White Matter Injury in Children With Cerebral Palsy: A Case-Control Study.Neurology · 2022Article
- Fetal intracranial hemorrhage in a case of 16p microdeletion.Case reports in perinatal medicine · 2022Article
- Ventriculosubgaleal shunt and neuroendoscopic lavage: refining the treatment algorithm of neonatal post-hemorrhagic hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine how the severity of antenatally diagnosed germinal matrix-intraventricular hemorrhage (GMH-IVH) relates to morbidity and mortality, and to explore potential risk factors.
methodWe conducted a systematic review and individual patient data meta-analysis of antenatally diagnosed fetal GMH-IVH. The primary outcomes were mortality and morbidity. Potential associations with clinical factors during pregnancy were explored. Analysis employed Fisher's exact test and logistic regression.
resultsWe included 240 cases from 80 studies. Presence of venous infarction was associated with mortality (odds ratio [OR] 4.3, 95% confidence interval [CI] 1.4-13.25), motor impairment (OR 103.2, 95% CI 8.6-1238), epilepsy (OR 6.46, 95% CI 2.64-16.06), and developmental delay (OR 8.55, 95% CI 2.12-48.79). Shunt placement was associated with gestational age at GMH-IVH diagnosis and in utero progression. Many cases had uncomplicated pregnancies but possible co-occurring conditions included twin gestation, small for gestational age, and congenital anomalies.
interpretationSeverity of fetal GMH-IVH, specifically venous infarction, is associated with overall mortality and morbidity. Risk factors for fetal GMH-IVH are poorly understood and controlled studies are required. WHAT THIS PAPER ADDS: Preterm germinal matrix-intraventricular hemorrhage (GMH-IVH) grading can be applied to fetuses. Many fetal germinal matrix hemorrhages occur in otherwise typical pregnancies. Half of fetuses with post-hemorrhagic ventricular dilatation receive a shunt after delivery. Fetuses with grade I or II GMH-IVH have few sequelae. Fetuses with periventricular hemorrhagic infarction have a high burden of motor impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.