ArticleJournal, genetic engineering & biotechnology2020
Antimicrobial metabolite profiling of Nigrospora sphaerica from Adiantum philippense L.
Article in Journal, genetic engineering & biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- Biological activities and metabolic profile of crude extracts from two Nigrospora sp. isolates.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Taxonomic and Phylogenetic Resolution of Novel Endophytic Arthrinium-like Fungi with an Updated Checklist ofLife (Basel, Switzerland) · 2026Article
- Extraction and Identification of the Bioactive Metabolites Produced byMolecules (Basel, Switzerland) · 2025Article
- Endophytic fungi ofSaudi journal of biological sciences · 2024Article
- Bioactive compounds and biomedical applications of endophytic fungi: a recent review.Microbial cell factories · 2023Review
- Fungal Endophytes: A Potential Source of Antibacterial Compounds.Journal of fungi (Basel, Switzerland) · 2022Review
- Phenolic and flavonoid contents and antioxidant activity of an endophytic fungus Nigrospora sphaerica (EHL2), inhabiting the medicinal plant Euphorbia hirta (dudhi) L.Archives of microbiology · 2022Article
- Epigenetic Modifiers Revamp Secondary Metabolite Production in EndophyticFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndophyte bestows beneficial aspects to its inhabiting host, along with a contribution to diverse structural attributes with biological potential. In this regard, antimicrobial profiling of fungal endophytes from medicinal plant Adiantum philippense revealed bioactive Nigrospora sphaerica from the leaf segment. Chemical and biological profiling through TLC-bioautography and hyphenated spectroscopic techniques confirmed the presence of phomalactone as an antimicrobial metabolite.
resultsThe chemical investigation of the broth extract by bioassay-guided fractionation confirmed phomalactone as a bioactive antimicrobial secondary metabolite. The antimicrobial activity of phomalactone was found to be highest against Escherichia coli by disc diffusion assay. The MIC was found to be significant against both Escherichia coli and Xanthomonas campestris in the case of bacteria and dermatophyte Candida albicans at 150 μg/ml, respectively.
conclusionsOverall, the results highlighted the antimicrobial potential of phomalactone from the endophyte Nigrospora sphaerica exhibiting a broad spectrum of antimicrobial activity against human and phytopathogenic bacteria and fungi. This work is the first report regarding the antibacterial activity of phomalactone.
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Registered trials
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