ArticleKidney medicine
Nephron Number and Time to Remission in Steroid-Sensitive Minimal Change Disease.
Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Response to the Letter by Tsuboi and Sasaki: "Integrating Podocyte Biology into the Two-Stage Remission Model".Kidney medicine · 2026Article
- Defining Complete Remission in Nephrotic Syndrome: One Size May Not Fit All.Kidney medicine · 2026Article
- Nephron Number and Kidney Outcomes in IgA Nephropathy: A Retrospective Cohort Study.Kidney360 · 2026Article
- Biopsy Morphometrics as Predictors of Treatment Response in Primary Nephrotic Syndrome.Kidney medicine · 2026Article
- Morphometric analysis of chronicity on kidney biopsy: a useful prognostic exercise.Clinical kidney journal · 2024Review
- Assessment of nephron number and single-nephron glomerular filtration rate in a clinical setting.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Review
- Nephron Number as Predictor of Corticosteroid Response in Adult Minimal Change Disease.Kidney medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE &
objectiveThe response to corticosteroid therapy may differ among patients with minimal change disease (MCD). Previous studies have suggested that glomerular hypertrophy or low areal glomerular density in biopsy specimens, which may be related to fewer nephrons, is associated with such a difference. We examined the associations between nephron number and the therapeutic response to corticosteroids in patients with MCD. STUDY
designRetrospective cohort study. SETTING &
participants75 adult patients with a histologic diagnosis of MCD. EXPOSURE: Nephron number per kidney estimated based on the combination of unenhanced computed tomography and nonsclerotic volumetric glomerular density in kidney biopsy specimens. OUTCOMES: Complete remission and relapse following corticosteroid therapy. ANALYTICAL APPROACH: Multivariable Cox proportional hazard analyses of associations between factors, including nephron number, and outcomes.
resultsMean age of patients was 45.9 years and 60.0% were men. Patients had an estimated glomerular filtration rate of 64.6 mL/min/1.73 m LIMITATION: Retrospective design and sampling bias of needle biopsy.
conclusionsA small nephron number in patients with MCD is associated with longer time to complete remission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.