Evidence map›Paper›PMID 33094212›Full record

ReviewAPL bioengineering2020

Fundamentals of light-cell-polymer interactions in photo-cross-linking based bioprinting.

Daniel Nieto, Juan Antonio Marchal Corrales, Alberto Jorge de Mora, Lorenzo Moroni

Abstract readReview
In one paragraph

Review in APL bioengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Computational approaches in bioprinting processes.Nature reviews bioengineering · 2026
    Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juan Antonio Marchal CorralesORCID https://orcid.org/0000-0002-4996-8261
Alberto Jorge de MoraSERGAS (Galician Health Service) and IDIS (Health Research Institute of Santiago de Compostela (IDIS), Orthopaedic Department, Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID https://orcid.org/0000-0003-0143-1323
Lorenzo MoroniComplex Tissue Regeneration Department, MERLN Institute for Technology Inspired Regenerative Medicine, Universiteitssingel 40, 6229ER Maastricht, The Netherlands.ORCID https://orcid.org/0000-0003-1298-6025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofabrication technologies that use light for polymerization of biomaterials have made significant progress in the quality, resolution, and generation of precise complex tissue structures. In recent years, the evolution of these technologies has been growing along with the development of new photocurable resins and photoinitiators that are biocompatible and biodegradable with bioactive properties. Such evolution has allowed the progress of a large number of tissue engineering applications. Flexibility in the design, scale, and resolution and wide applicability of technologies are strongly dependent on the understanding of the biophysics involved in the biofabrication process. In particular, understanding cell-light interactions is crucial when bioprinting using cell-laden biomaterials. Here, we summarize some theoretical mechanisms, which condition cell response during bioprinting using light based technologies. We take a brief look at the light-biomaterial interaction for a better understanding of how linear effects (refraction, reflection, absorption, emission, and scattering) and nonlinear effects (two-photon absorption) influence the biofabricated tissue structures and identify the different parameters essential for maintaining cell viability during and after bioprinting.

Identifiers

PMID33094212
PMCPMC7553782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.