Evidence map›Paper›PMID 33094118›Full record

ArticleOpen forum infectious diseases2020

Omadacycline for the Treatment of

Jeffrey C Pearson, Brandon Dionne, Aaron Richterman, Samuel J Vidal, Zoe Weiss, Gustavo E Velásquez, Francisco M Marty, Paul E Sax, Sigal Yawetz

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. A systematic review of tetracyclines for nontuberculous mycobacteria: focus on rapidly growing mycobacteria.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Antimicrobial agents and chemotherapy · 2024
    Article
  12. Review
  13. Therapy ofMicroorganisms · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeffrey C PearsonDepartment of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-5276-1050
Brandon DionneDepartment of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Aaron RichtermanDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-7920-7191
Samuel J VidalDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Zoe WeissDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Gustavo E VelásquezDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Francisco M MartyDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-3708-8734
Paul E SaxDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sigal YawetzDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
Safety and tolerability of new and repurposed drugs for MDR-TB treatmentK08AI141740 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VELASQUEZ, GUSTAVO EDUARDO · 2019 to 2023
$985k
NIAID NIH HHS K08 AI141740NIAID NIH HHS L30 AI120170NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007387
6 · The paper itself

Abstract

backgroundOmadacycline is an aminomethylcycline antimicrobial approved by the US Food and Drug Administration in 2018 for community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It has in vitro activity against nontuberculous mycobacteria, including

methodsOmadacycline use was reviewed at an 804-bed academic medical center. Patients were included if they received omadacycline for culture-proven

resultsFour patients received omadacycline for the treatment of culture-positive

conclusionsOmadacycline is a novel oral option for the treatment of

Indexed as

mycobacterial infectionsMycobacterium abscessusnontuberculous mycobacteriaomadacycline

Identifiers

PMID33094118
PMCPMC7566545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.