Evidence map›Paper›PMID 33094029›Full record

ArticleAIP advances2020

Transient acoustic vaporization signatures unique to low boiling point phase change contrast agents enable super-resolution ultrasound imaging without spatiotemporal filtering.

R M DeRuiter, E N Markley, J D Rojas, G F Pinton, P A Dayton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIP advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

R M DeRuiterJoint Department of Biomedical Engineering, University of North Carolina-Chapel Hill and North Carolina State University, 116 Manning Drive, 9018 Mary Ellen Jones Building, CB7575, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0003-2135-6607
E N MarkleyJoint Department of Biomedical Engineering, University of North Carolina-Chapel Hill and North Carolina State University, 116 Manning Drive, 9018 Mary Ellen Jones Building, CB7575, Chapel Hill, North Carolina 27599, USA.
J D RojasJoint Department of Biomedical Engineering, University of North Carolina-Chapel Hill and North Carolina State University, 116 Manning Drive, 9018 Mary Ellen Jones Building, CB7575, Chapel Hill, North Carolina 27599, USA.
G F PintonJoint Department of Biomedical Engineering, University of North Carolina-Chapel Hill and North Carolina State University, 116 Manning Drive, 9018 Mary Ellen Jones Building, CB7575, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0002-4896-1439
P A DaytonJoint Department of Biomedical Engineering, University of North Carolina-Chapel Hill and North Carolina State University, 116 Manning Drive, 9018 Mary Ellen Jones Building, CB7575, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0002-5757-6911

Funding

High Frame Rate 3-D Super Resolution Ultrasound Microvascular ImagingR01CA220681 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAYTON, PAUL A, PINTON, GIANMARCO · 2017 to 2022
$3.0M
An academic industrial partnership for the development of high frame-rate transcranial super resolution ultrasound imagingR01EB025149 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAYTON, PAUL A, PINTON, GIANMARCO · 2017 to 2018
$935k
Fast volumetric treatment using multi-focus insonation and thermal amplificationR21EB021012 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASKEY, CHARLES F · 2016 to 2017
$441k
NCI NIH HHS R01 CA220681NIBIB NIH HHS R01 EB025149NIBIB NIH HHS R21 EB021012
6 · The paper itself

Abstract

The unique activation signal of phase-change contrast agents (PCCAs or droplets) can be separated from the tissue signal and localized to generate super-resolution (SR) ultrasound (US) images. Lipid-shelled, perfluorocarbon PCCAs can be stochastically vaporized (activated) by a plane wave US transmission thereby enabling them to be used as separable targets for ultrasound localization microscopy. The unique signature of droplet vaporization imaging and the transient inherent nature of this signature increases signal contrast and therefore localization confidence, while the poor resolution of the low-frequency vaporization signal is overcome by the super-resolution result. Furthermore, our proposed PCCA SR technique does not require the use of user-dependent and flow-dependent spatio-temporal filtering via singular-value decomposition. Rather, matched filters selected by Fourier-domain analysis are able to identify and localize PCCA activations. Droplet SR was demonstrated in a crossed-microtube water phantom by localizing the activation signals of octafluoropropane nanodroplets (OFP, C

Identifiers

PMID33094029
PMCPMC7575328

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.