Evidence map›Paper›PMID 33093876›Full record

ArticlePolymer chemistry2019

3D Printable Non-Isocyanate Polyurethanes with Tunable Material Properties.

John J Warner, Pengrui Wang, William M Mellor, Henry H Hwang, Ji Hoon Park, Sang-Hyun Pyo, Shaochen Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

John J WarnerDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Pengrui WangDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
William M MellorDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Henry H HwangDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
Ji Hoon ParkCarbon Resources Institute, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Republic of Korea.
Sang-Hyun PyoBiotechnology, Department of Chemistry, Center for Chemistry and Chemical Engineering, Lund University, Box 124, 221 00 Lund, Sweden.
Shaochen ChenDepartment of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
University of California System · USGovernment of the Republic of Korea · KRLund University · SE

Funding

Rapid 3D bioprinting of biomimetic vascularized tissue constructsR01EB021857 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, DOKMECI, MEHMET REMZI · 2016 to 2019
$2.1M
3D Printing of Precision Scaffolds for Volumetric Muscle Tissue RegenerationR21AR074763 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2019 to 2020
$355k
NIAMS NIH HHS R21 AR074763NIBIB NIH HHS R01 EB021857
6 · The paper itself

Abstract

Green chemistry-based non-isocyanate polyurethanes (NIPU) are synthesized and 3D-printed via rapid, projection photopolymerization into compliant mechanisms of 3D structure with spatially-localized material properties. Trimethylolpropane allyl ether-cyclic carbonate is used to couple the unique properties of two types of reaction chemistry: (1) primary diamine-cyclic carbonate ring-opening conjugation for supplanting conventional isocyanate-polyol reactions in creating urethane groups, with the additional advantage of enabling modular segment interchangeability within the diurethane prepolymers; and (2) thiol-ene (click) conjugation for non-telechelic, low monodispersity, quasi-crystalline-capable, and alternating step-growth co-photopolymerization. Fourier Transform Infrared Spectroscopy is used to monitor the functional group transformation in reactions, and to confirm these process-associated molecular products. The extent of how these processes utilize molecular tunability to affect material properties were investigated through measurement-based comparison of the various polymer compositions: frequency-related dynamic mechanical analysis, tension-related elastic-deformation mechanical analysis, and material swelling analysis. Stained murine myoblasts cultured on NIPU slabs were evaluated via fluorescent microscopy for "green-chemistry" affects on cytocompatibility and cell adhesion to assess potential biofouling resistance. 3D multi-material structures with micro-features were printed, thus demonstrating the capability to spatially pattern different NIPU materials in a controlled manner and build compliant mechanisms.

Identifiers

PMID33093876
PMCPMC7577587
OpenAlexW2963258505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.