Evidence map›Paper›PMID 33093794›Full record

ArticleMaterials today (Kidlington, England)

Overcoming blood-brain barrier transport: Advances in nanoparticle-based drug delivery strategies.

Shichao Ding, Aminul Islam Khan, Xiaoli Cai, Yang Song, Zhaoyuan Lyu, Dan Du, Prashanta Dutta, Yuehe Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today (Kidlington, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed.

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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shichao DingSchool of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
Aminul Islam KhanSchool of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
Xiaoli CaiSchool of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
Yang SongSchool of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
Zhaoyuan LyuSchool of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
Dan DuSchool of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
Prashanta DuttaSchool of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
Yuehe LinSchool of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.

Funding

Multiscale Modeling of Transport though Blood Brain BarrierR01GM122081 · NIGMS · WASHINGTON STATE UNIVERSITY · PI DUTTA, PRASHANTA · 2016 to 2018
$763k
NIGMS NIH HHS R01 GM122081
6 · The paper itself

Abstract

The Blood-Brain Barrier (BBB), a unique structure in the central nervous system (CNS), protects the brain from bloodborne pathogens by its excellent barrier properties. Nevertheless, this barrier limits therapeutic efficacy and becomes one of the biggest challenges in new drug development for neurodegenerative disease and brain cancer. Recent breakthroughs in nanotechnology have resulted in various nanoparticles (NPs) as drug carriers to cross the BBB by different methods. This review presents the current understanding of advanced NP-mediated non-invasive drug delivery for the treatment of neurological disorders. Herein, the complex compositions and special characteristics of BBB are elucidated exhaustively. Moreover, versatile drug nanocarriers with their recent applications and their pathways on different drug delivery strategies to overcome the formidable BBB obstacle are briefly discussed. In terms of significance, this paper provides a general understanding of how various properties of nanoparticles aid in drug delivery through BBB and usher the development of novel nanotechnology-based nanomaterials for cerebral disease therapies.

Indexed as

blood-brain barrierdrug deliverynanoparticletranscytosis

Identifiers

PMID33093794
PMCPMC7575138

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.