ReviewThe Ulster medical journal2020
Diverticular Disease: A Review on Pathophysiology and Recent Evidence.
Review in The Ulster medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Faecal Calprotectin: A Non-Invasive Marker for Diagnosing and Monitoring Acute Diverticulitis.Medical sciences (Basel, Switzerland) · 2026Review
- Sequential pancreatitis and diverticulitis following elective anterior lumbar disc replacement: a case report of a rare postoperative domino effect.International journal of surgery case reports · 2026Article
- Segmental Colitis Associated with Diverticulosis: Status Quo.Journal of clinical medicine · 2026Review
- Artificial intelligence in optimizing antimicrobial therapy for gastro-renal disorders.Frontiers in cellular and infection microbiology · 2026Review
- Bowel Transit Time May Be Accelerated in Colonic Diverticulosis Independent of Mucosal Serotonin Signaling.Journal of clinical medicine · 2025Article
- Jejunal diverticular disease: A gastrointestinal bleeding enigma.World journal of gastrointestinal pathophysiology · 2025Review
- Case Report: Chronic Prostatitis as an Extraintestinal Manifestation of Ulcerative Colitis.IJU case reports · 2025Article
- Multiple jejunal diverticulosis, from an anatomical and histological view: A case report.World journal of gastrointestinal surgery · 2025Article
- Parameters of Body Composition Predict Clinical Course in Acute Colonic Diverticulitis.Journal of cachexia, sarcopenia and muscle · 2025Article
- Assessing the Role of Follow-Up Investigations After Acute Diverticulitis in Detecting Colorectal Cancer.Cureus · 2025Article
- Sex-Specific Multimorbidity-Multibehaviour Patterns in Primary Care Populations.International journal of environmental research and public health · 2025Observational
- Gallbladder perforation due to the obstructing periampullary duodenal diverticulum (Lemmel's syndrome): a case report.Journal of surgical case reports · 2025Article
- From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases - Opportunity or Challenge?Journal of inflammation research · 2025Review
- Article
- Complicated diverticulitis: Diagnostic precision and surgical solutions in a patient with chronic kidney disease.Radiology case reports · 2025Article
- Triple Colonic Fistula Due to Complicated Diverticular Disease and Its Surgical Management.Cureus · 2024Article
- Patient Perspectives on Evolving Diverticulitis Treatment: An Assessment of Patient Willingness to Enroll in a Randomized Controlled Trial.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Clinical features and risk factors for appendiceal diverticulitis: a comparative study with acute appendicitis.Surgery today · 2024Article
- Article
- Clinical and Radiographic Characteristics in Segmental Colitis Associated With Diverticulosis, Diverticulitis, and Crohn's Disease.Gastro hep advances · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverticular disease is common condition globally, especially in Western countries. Diverticulitis, Symptomatic uncomplicated Diverticular disease and Segmental Colitis associated with diverticula constitute diverticular disease. Although most patients with diverticula are asymptomatic, around 25% of patients will experience symptoms whilst 5% of patients have an episode of acute diverticulitis. The prevalence increases with age with more than one theory being put forward to explain its pathogenesis. Faecolith entrapment in diverticula results in colonic mucosal damage and oedema, bacterial proliferation and toxin accumulation leading to perforation. This mechanism may explain diverticulitis in elderly patients with multiple, larger diverticula. Ischaemic damage could be the cause of acute diverticulitis in younger patients with sparse diverticula where more frequent and forceful muscular contractions in response to colonic stimuli occlude the vasculature leading to ischaemia and microperforation. Chronic colonic active inflammation in the presence of diverticular disease is termed Segmental colitis associated with diverticulosis. Its pathophysiology is still indeterminate but together with its clinical picture, may mimic Inflammatory Bowel Disease. Treatment includes a high fibre diet together with antibiotics and/or salicylates with surgery in severe cases. Indications for elective surgery in diverticular disease have changed over the past decades as this may not suggest a reduction in morbidity and mortality. Prophylaxis with probiotics, laxatives, anti-spasmotics, anticholinergic drugs and salicylates are at the centre of recent studies. Studies are also challenging previously believed facts regarding dietary fibre, nuts and seeds whilst emphasizing the effect of healthy lifestyle and smoking on the increasing incidence of DD.
Indexed as
Identifiers
33093692PMC7576390W3094457874What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.