Evidence map›Paper›PMID 33093626›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2021

Association of chorioamnionitis and patent ductus arteriosus in a national U.S. cohort.

Celeste A Green, Daniel Westreich, Matthew M Laughon, David M Stamilio, Robert A Strauss, Jeff Reese, Elaine L Shelton, Kartik K Venkatesh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Maternal Immune Activation: Implications for Congenital Heart Defects.Clinical reviews in allergy & immunology · 2025
    Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Celeste A GreenDepartment of Obstetrics and Gynecology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-1773-9296
Daniel WestreichDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
Matthew M LaughonDivision of Neonatal Perinatal Medicine, Department of Pediatrics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-4052-3215
David M StamilioDepartment of Obstetrics and Gynecology, Wake Forest University, Winston-Salem, NC, USA.
Robert A StraussDepartment of Obstetrics and Gynecology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
Jeff ReeseDepartment of Pediatrics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-8751-6146
Elaine L SheltonDepartment of Pediatrics, Vanderbilt University, Nashville, TN, USA.
Kartik K VenkateshDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, OH, USA. kartik.venkatesh@osumc.edu.ORCID http://orcid.org/0000-0002-8043-556X
University of North Carolina at Chapel Hill · USVanderbilt University · USThe Ohio State University · USWake Forest University · US

Funding

Pharmacological Validation of Vascular KATP Channels for Modulating Ductus Arteriosus ToneR01HD099777 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENTON, JEROD S., SHELTON, ELAINE · 2020 to 2023
$2.3M
Mentorship of Early-Career Clinicians in Bronchopulmonary Dysplasia Drug TherapiesK24HL143283 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2019 to 2023
$613k
NHLBI NIH HHS K24 HL143283NICHD NIH HHS HHSN267200603425CNICHD NIH HHS R01 HD099777
6 · The paper itself

Abstract

objectiveTo estimate the effect of clinical chorioamnionitis on the risk of patent ductus arteriosus (PDA). STUDY

designA secondary analysis of all deliveries >23 gestational weeks from the U.S. Consortium on Safe Labor (CSL) study. The primary exposure was a clinical diagnosis of chorioamnionitis, and the outcome was a diagnosis of PDA. Generalized estimating equations with estimated error variance for women with multiple deliveries were utilized. Models adjusted for age, race, region, delivery year, body mass index, infant sex, multiple gestation, mode of delivery, and antenatal corticosteroid exposure.

resultsAmong 228,438 deliveries, a diagnosis of PDA was more frequent with chorioamnionitis exposure versus without (9.2% vs. 3.0%; OR: 3.25; 95% CI: 2.92-3.62). Chorioamnionitis was associated with higher adjusted odds of PDA (AOR: 2.18; 95% CI: 1.93-2.45). In sensitivity analyses, the association between chorioamnionitis and PDA held after adjustment for gestational age at delivery (AOR: 1.28; 95% CI: 1.13-1.44).

conclusionsChorioamnionitis was associated with increased odds of PDA. Robust exposure and outcome ascertainment with careful assessment of confounding is needed to further investigate this epidemiologic association.

Indexed as

ChorioamnionitisDuctus Arteriosus, PatentCohort StudiesFemaleGestational AgeHumansInfantPregnancyPregnancy, Multiple

Identifiers

PMID33093626
PMCPMC8788109
OpenAlexW3093662274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.