Evidence map›Paper›PMID 33093610›Full record

ArticleScientific reports2020

Fast, large area multiphoton exoscope (FLAME) for macroscopic imaging with microscopic resolution of human skin.

Alexander Fast, Akarsh Lal, Amanda F Durkin, Griffin Lentsch, Ronald M Harris, Christopher B Zachary, Anand K Ganesan, Mihaela Balu

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Advances in wound care · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander FastBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd., Irvine, CA, 92612, USA.
Akarsh LalBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd., Irvine, CA, 92612, USA.
Amanda F DurkinBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd., Irvine, CA, 92612, USA.
Griffin LentschBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd., Irvine, CA, 92612, USA.
Ronald M HarrisDepartment of Dermatology, University of California, Irvine, 1 Medical Plaza Dr., Irvine, CA, 92697, USA.
Christopher B ZacharyDepartment of Dermatology, University of California, Irvine, 1 Medical Plaza Dr., Irvine, CA, 92697, USA.
Anand K GanesanDepartment of Dermatology, University of California, Irvine, 1 Medical Plaza Dr., Irvine, CA, 92697, USA.
Mihaela BaluBeckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Rd., Irvine, CA, 92612, USA. mbalu@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2012 to 2017
$7.0M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Development of a fast scanning, extended field-of-view multiphoton microscope for clinical skin imagingR01EB026705 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mihaela Balu, Anand K Ganesan · 2018 to 2026
$4.2M
Quantitative multiphoton microscopy for non-invasive diagnosis of melanomaR01CA195466 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BALU, MIHAELA, KELLY, KRISTEN M · 2016 to 2018
$825k
NCI NIH HHS P30 CA062203NCI NIH HHS R01CA19546NCI NIH HHS R01 CA195466NCI NIH HHS T32 CA009054NCI NIH HHS T32CA009054NIAMS NIH HHS P30 AR075047NIBIB NIH HHS P41 EB015890NIBIB NIH HHS R01 EB026705NIBIB NIH HHS R01EB026705NIH HHS P30AR075047
6 · The paper itself

Abstract

We introduce a compact, fast large area multiphoton exoscope (FLAME) system with enhanced molecular contrast for macroscopic imaging of human skin with microscopic resolution. A versatile imaging platform, FLAME combines optical and mechanical scanning mechanisms with deep learning image restoration to produce depth-resolved images that encompass sub-mm

Indexed as

HumansImage Processing, Computer-AssistedMelaninsMelanocytesMicroscopy, Fluorescence, MultiphotonSkinMelanins

Identifiers

PMID33093610
PMCPMC7582965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.