ArticleNature communications2020
Social attraction in Drosophila is regulated by the mushroom body and serotonergic system.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Environmental modulation of social isolation-induced sleep loss inbioRxiv : the preprint server for biology · 2026Article
- Sociability is a Multidimensional Trait in Drosophila melanogaster.Behavior genetics · 2026Article
- Drospondin, a glial glycoprotein with similarities to human Reelin/F-spondin, contributes toProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lateralized and bilateral sensory mechanisms independently regulate sociability and social preference inFrontiers in behavioral neuroscience · 2026Article
- Phonotaxis in Male Field Crickets: The Role of Flight Experience, Serotonin and Octopamine Neurotransmission.Insects · 2025Article
- The foraging gene coordinates brain and heart networks to modulate socially cued interval timing in Drosophila.PLoS genetics · 2025Article
- Movement and Dispersion Parameters Characterizing the Group Behavior ofAnimals : an open access journal from MDPI · 2025Article
- Ancestral complexity and constrained diversification of the ant olfactory system.Proceedings. Biological sciences · 2025Article
- Chemical signals and social structures strengthen sexual isolation in Drosophila pseudoobscura.Communications biology · 2025Article
- Review
- An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- The gene "degrees of kevin bacon" (dokb) regulates a social network behaviour in Drosophila melanogaster.Nature communications · 2024Article
- The human neuropsychiatric risk gene Drd2 is necessary for social functioning across evolutionary distant species.Molecular psychiatry · 2024Article
- Peer-induced quiescence of maleFrontiers in behavioral neuroscience · 2024Article
- Sex Differences in Sociability formicroPublication biology · 2024Article
- Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.Acta neuropathologica communications · 2023Article
- DVT: a high-throughput analysis pipeline for locomotion and social behavior in adult Drosophila melanogaster.Cell & bioscience · 2023Article
- Article
- Taste coding of heavy metal ion-induced avoidance iniScience · 2023Article
- Navigating Like a Fly:International journal of molecular sciences · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sociality is among the most important motivators of human behaviour. However, the neural mechanisms determining levels of sociality are largely unknown, primarily due to a lack of suitable animal models. Here, we report the presence of a surprising degree of general sociality in Drosophila. A newly-developed paradigm to study social approach behaviour in flies reveal that social cues perceive through both vision and olfaction converged in a central brain region, the γ lobe of the mushroom body, which exhibite activation in response to social experience. The activity of these γ neurons control the motivational drive for social interaction. At the molecular level, the serotonergic system is critical for social affinity. These results demonstrate that Drosophila are highly sociable, providing a suitable model system for elucidating the mechanisms underlying the motivation for sociality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.