Evidence map›Paper›PMID 33093240›Full record

ArticleJournal of cell science2020

Endophilin-A2-dependent tubular endocytosis promotes plasma membrane repair and parasite invasion.

Matthias Corrotte, Mark Cerasoli, Fernando Y Maeda, Norma W Andrews

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Caveolae mechanics in cellular functions and disease.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. Review
  4. Membrane Tension Regulation is Required for Wound Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthias CorrotteDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Mark CerasoliDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Fernando Y MaedaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Norma W AndrewsDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA andrewsn@umd.edu.ORCID 0000-0002-0611-2412
University of Maryland, College Park · USVirginia–Maryland College of Veterinary Medicine · US

Funding

Regulated exocytosis of lysosomes and plasma membrane repairR01GM064625 · NIGMS · YALE UNIVERSITY · PI ANDREWS, NORMA WINDSOR, SONG, WENXIA · 2002 to 2020
$6.3M
NIGMS NIH HHS R01 GM064625
6 · The paper itself

Abstract

Endocytosis of caveolae has previously been implicated in the repair of plasma membrane wounds. Here, we show that caveolin-1-deficient fibroblasts lacking caveolae upregulate a tubular endocytic pathway and have a reduced capacity to reseal after permeabilization with pore-forming toxins compared with wild-type cells. Silencing endophilin-A2 expression inhibited fission of endocytic tubules and further reduced plasma membrane repair in cells lacking caveolin-1, supporting a role for tubular endocytosis as an alternative pathway for the removal of membrane lesions. Endophilin-A2 was visualized in association with cholera toxin B-containing endosomes and was recruited to recently formed intracellular vacuoles containing

Indexed as

Cell MembraneEndocytosisTrypanosoma cruzi3T3 CellsAcyltransferasesAnimalsCaveolaeClathrinMice2-acylglycerophosphate acyltransferaseAcyltransferasesClathrinEndocytosisEndophilinPlasma membrane repair

Identifiers

PMID33093240
PMCPMC7725609
OpenAlexW3093575313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.