Evidence map›Paper›PMID 33093130›Full record

ArticleBMJ open diabetes research & care2020

Prevalence, incidence and predictors of cardiovascular risk factors: longitudinal data from rural and urban South India and comparison with global data.

Senthil K Vasan, Belavendra Antonisamy, Mahasampath Gowri, Hepsy Y Selliah, Finney S Geethanjali, Felix S Jebasingh, Thomas V Paul, Nihal Thomas, Fredrik Karpe, Matthew Johnson and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Senthil K Vasan *Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK senthil.vasan@ocdem.ox.ac.uk.ORCID 0000-0002-3630-6568
Belavendra Antonisamy *Department of Biostatistics, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Mahasampath GowriDepartment of Biostatistics, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Hepsy Y SelliahDepartment of Biostatistics, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Finney S GeethanjaliDepartment of Clinical Biochemistry, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Felix S JebasinghDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Thomas V PaulDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Nihal ThomasDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.ORCID 0000-0002-2751-1770
Matthew JohnsonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, Hampshire, UK.ORCID 0000-0001-5597-6615
Clive OsmondMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, Hampshire, UK.
Caroline H D FallMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, Hampshire, UK.
Christian Medical College, Vellore · INMRC Lifecourse Epidemiology Unit · GBUniversity of Oxford · GB

Funding

British Heart Foundation BHF_CS/15/4/31493British Heart Foundation BHF_RG/98001British Heart Foundation CRM: 0022324British Heart Foundation CS/15/4/31493Medical Research Council G0400519Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_12011/3
6 · The paper itself

Abstract

introductionIndia has high mortality rates from cardiovascular disease (CVD). Understanding the trends and identifying modifiable determinants of CVD risk factors will guide preventive strategies and policy making. RESEARCH DESIGN AND

methodsCVD risk factors (obesity, central obesity, and type 2 diabetes (T2D), hypertension, hypercholesterolemia and hypertriglyceridemia) prevalence and incidence were estimated in 962 (male 519) non-migrant adults from Vellore, South India, studied in: (1) 1998-2002 (mean age 28.2 years) and (2) 2013-2014 (mean age 41.7 years). Prevalence was compared with the Non-Communicable Disease Risk Collaboration (global) data. Incidence was compared with another Indian cohort from New Delhi Birth Cohort (NDBC). Regression analysis was used to test baseline predictors of incident CVD risk factors.

resultsThe prevalence at 28 and 42 years was 17% (95% CI 14% to 19%) and 51% (95% CI 48% to 55%) for overweight/obesity, 19% (95% CI 17% to 22%) and 59% (95% CI 56% to 62%) for central obesity, 3% (95% CI 2% to 4%) and 16% (95% CI 14% to 19%) for T2D, 2% (95% CI 1% to 3%) and 19% (95% CI 17% to 22%) for hypertension and 15% (95% CI 13% to 18%) and 30% (95% CI 27% to 33%) for hypertriglyceridemia. The prevalence of T2D at baseline and follow-up and hypertension at follow-up was comparable with or exceeded that in high-income countries despite lower obesity rates. The incidence of most risk factors was lower in Vellore than in the NDBC. Waist circumference strongly predicted incident T2D, hypertension and hypertriglyceridemia.

conclusionsA high prevalence of CVD risk factors was evident at a young age among Indians compared with high and upper middle income countries, with rural rates catching up with urban estimates. Adiposity predicted higher incident CVD risk, but the prevalence of hypertension and T2D was higher given a relatively low obesity prevalence. Preventive efforts should target both rural and urban India and should start young.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2AdultHumansIncidenceIndiaMalePrevalencecardiovascular systemdiabetes mellitusrisk factorstype 2

Identifiers

PMID33093130
PMCPMC7583064
OpenAlexW3093642030

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.