ReviewJournal of the American College of Cardiology2020
Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC Focus Seminar.
Review in Journal of the American College of Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 6 syntheses or guidelines pooled it, 230 citations in OpenAlex.
- Cardiac involvement in coronavirus disease 2019 assessed by cardiac magnetic resonance imaging: a meta-analysis.Heart and vessels · 2022Pooled it
- Abnormal Echocardiographic Findings in Hospitalized Patients with Covid-19: A Systematic Review and Meta-analysis.Arquivos brasileiros de cardiologia · 2022Pooled it
- Comparison of Coronary Artery Involvement and Mortality in STEMI Patients With and Without SARS-CoV-2 During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis.Current problems in cardiology · 2022Pooled it
- Echocardiographic assessment of the right ventricle in COVID-19: a systematic review.The international journal of cardiovascular imaging · 2021Pooled it
- COVID-19 in heart transplant recipients during February-August 2020: A systematic review.Clinical transplantation · 2021Pooled it
- Echocardiography, lung ultrasound, and cardiac magnetic resonance findings in COVID-19: A systematic review.Echocardiography (Mount Kisco, N.Y.) · 2021Pooled it
- Does COVID-19 Vaccination Protect Against Post-COVID Cardiovascular Conditions?Reviews in medical virology · 2026Review
- Association between galectin-3 and echocardiographic changes in hospitalized patients with coronavirus disease 2019: A retrospective observational study.The Journal of international medical research · 2026Observational
- Randomized clinical trials of COVID-19 vaccines are not designed to study non-specific effects on rare mortality.iScience · 2026Article
- COVID-19 and cardiovascular outcomes in patients with pre-existing hypertension.Journal of human hypertension · 2026Review
- Myocardial oxygen consumption, myocardial efficiency, and mechanical efficiency: A review across pathologic and physiologic states.Physiological reports · 2026Review
- Cardiovascular Risks of COVID-19 Therapeutics: Integrated Analysis of FAERS, Electronic Health Records, and Transcriptomics.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Effects of Respiratory Vaccines in Older Adults with Cardiovascular Diseases: A Scoping Review.Vaccines · 2026Review
- Article
- Trends in mortality due to acute myocardial infarction and pneumonia among older adults in the U.S.: a CDC wonder analysis (1999-2023).Frontiers in cardiovascular medicine · 2026Article
- Long-Term Cardiovascular and Mortality Risk in Patients with Pre-Existing Arrhythmia Post-SARS-CoV-2 Infection.Diagnostics (Basel, Switzerland) · 2025Article
- Elevated Risk of Long-Term Decline in Left Ventricular Ejection Fraction After COVID-19.Journal of the American Heart Association · 2025Article
- Article
- Global, Regional, and National Time Trends in Mortality for Ischemic Heart Disease, 1990-2019: An Age-Period-Cohort Analysis for the Global Burden of Disease 2019 Study.Reviews in cardiovascular medicine · 2025Article
- Cardiovascular Complications of COVID-19 Disease: A Narrative Review.Diseases (Basel, Switzerland) · 2025Review
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The cardiovascular system is affected broadly by severe acute respiratory syndrome coronavirus 2 infection. Both direct viral infection and indirect injury resulting from inflammation, endothelial activation, and microvascular thrombosis occur in the context of coronavirus disease 2019. What determines the extent of cardiovascular injury is the amount of viral inoculum, the magnitude of the host immune response, and the presence of co-morbidities. Myocardial injury occurs in approximately one-quarter of hospitalized patients and is associated with a greater need for mechanical ventilator support and higher hospital mortality. The central pathophysiology underlying cardiovascular injury is the interplay between virus binding to the angiotensin-converting enzyme 2 receptor and the impact this action has on the renin-angiotensin system, the body's innate immune response, and the vascular response to cytokine production. The purpose of this review was to describe the mechanisms underlying cardiovascular injury, including that of thromboembolic disease and arrhythmia, and to discuss their clinical sequelae.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.