Evidence map›Paper›PMID 33092608›Full record

Observational studyVirology journal2020

Italian observational study on HPV infection, E6, and p16 expression in men with penile cancer.

Narcisa Muresu, Giovanni Sotgiu, Laura Saderi, Illari Sechi, Antonio Cossu, Vincenzo Marras, Marta Meloni, Marianna Martinelli, Clementina Cocuzza, Francesco Tanda and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Virology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Narcisa MuresuDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Via Padre Manzella, 4, 07100, Sassari, Italy.
Giovanni SotgiuDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Via Padre Manzella, 4, 07100, Sassari, Italy. gsotgiu@uniss.it.ORCID 0000-0002-1600-4474
Laura SaderiDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Via Padre Manzella, 4, 07100, Sassari, Italy.
Illari SechiDepartment of Biomedical Sciences, University of Sassari, 07100, Sassari, Italy.
Antonio CossuDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Via Padre Manzella, 4, 07100, Sassari, Italy.
Vincenzo MarrasDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Via Padre Manzella, 4, 07100, Sassari, Italy.
Marta MeloniDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Via Padre Manzella, 4, 07100, Sassari, Italy.
Marianna MartinelliDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900, Monza, Italy.
Clementina CocuzzaDepartment of Medicine and Surgery, University of Milano-Bicocca, 20900, Monza, Italy.
Francesco TandaDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Via Padre Manzella, 4, 07100, Sassari, Italy.
Andrea PianaDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Via Padre Manzella, 4, 07100, Sassari, Italy.
University of Sassari · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman Papillomavirus (HPV) infection is one of the most important causes of cancer. It can play a role in cervical and extra-cervical cancers. Penile cancer is rare, even if an increasing trend was recently reported. Aim of the present study was to assess the prevalence and distribution of HPV genotypes in cases of penile cancer diagnosed in Sardinia, Italy. Surrogate markers of HPV infection (i.e., E6 and p16 genes) were also evaluated in all cases.

methodsAn observational, retrospective study which recruited all cases of penile cancer diagnosed between 2002 and 2019 at a tertiary care hospital in Sardinia, Italy, was carried out. HPV-DNA detection and genotyping were performed by Real-time PCR. Specimens were tested for oncogene E6 mRNA and for p16(INK4a) expression.

resultsHPV prevalence was 28.1% (9/32); HPV-16 was the most prevalent genotype (7/9, 77.8%). p16INK4a positivity was found in 66.7% of the samples with a statistically significant difference between HPV-positive and -negative groups. E6-transcript was detected in 71% of the HPV-16 positive samples. The overall survival was not statistically different between HPV-positives and -negatives. DISCUSSION: The present study confirms the etiologic role of HPV in penile cancer and supports the adoption of vaccination strategies in men and women. Further studies should clarify the diagnostic and prognostic role of E6 and p16 proteins.

conclusionHPV infection can favor the occurrence of penile cancer, whose diagnosis and prognosis could be improved with the implementation of validated molecular techniques.

Indexed as

AgedCyclin-Dependent Kinase Inhibitor p16DNA, ViralHospitals, UniversityHumansMaleMiddle AgedOncogene Proteins, ViralPapillomaviridaePapillomavirus InfectionsPenile NeoplasmsRepressor ProteinsRetrospective StudiesTertiary Care CentersCyclin-Dependent Kinase Inhibitor p16DNA, ViralE6 protein, Human papillomavirus type 16Oncogene Proteins, ViralRepressor ProteinsE6HPVHPV-DNAp16Penile cancer

Identifiers

PMID33092608
PMCPMC7579865
OpenAlexW3094388603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.