Evidence map›Paper›PMID 33092570›Full record

Observational studyBMC surgery2020

Mesoglycan for pain control after open excisional HAEMOrrhoidectomy (MeHAEMO): an observational multicentre study on behalf of the Italian Society of Colorectal Surgery (SICCR).

G Gallo, S Di Saverio, G Clerico, A Sturiale, M Manigrasso, A Realis Luc, M Trompetto, G Sammarco, MeHAEMO Working Group

Erratum issued Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04481698 (Mesoglycan for Pain Control After Open Excisional HAEMOrrhoidectomy), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04481698 completednot on this map

Mesoglycan for Pain Control After Open Excisional HAEMOrrhoidectomy (MeHAEMO): An Observational Multicentre Study on Behalf of the Italian Society of Colorectal Surgery (SICCR)

TypeobservationalSponsorSocieta Italiana di Chirurgia ColoRettaleRan2017 to 2017Enrolled398ConditionsHaemorrhoidal Disease, Post-operative Pain, ThrombosisArmsMesoglycan
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

G GalloDepartment of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy. gaetanogallo1988@gmail.com.ORCID http://orcid.org/0000-0003-1066-4671
S Di SaverioDepartment of General Surgery, University of Insubria, Varese, Italy.
G ClericoDepartment of Colorectal Surgery, S. Rita Clinic, Vercelli, Italy.
A SturialeProctology and Pelvic Floor Clinical Centre, Cisanello University Hospital, Pisa, Italy.
M ManigrassoDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
A Realis LucDepartment of Colorectal Surgery, S. Rita Clinic, Vercelli, Italy.
M TrompettoDepartment of Colorectal Surgery, S. Rita Clinic, Vercelli, Italy.
G SammarcoDepartment of Health Sciences, University of Catanzaro, Catanzaro, Italy.
MeHAEMO Working Group
Bureau Veritas (France) · FRFederico II University Hospital · ITOspedale Cisanello · ITUniversity of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExcisional haemorrhoidectomy is the gold standard technique in patients with III and IV degree haemorrhoidal disease (HD). However, it is associated with a significant rate of post-operative pain. The aim of our study was to evaluate the efficacy of mesoglycan in the post-operative period of patients who underwent open excisional diathermy haemorrhoidectomy (OEH).

methodsThis was a retrospective multicentre observational study. Three hundred ninety-eight patients from sixteen colorectal referral centres who underwent OEH for III and IV HD were enrolled. All patients were followed-up on the first post-operative day (T1) and after 1 week (T2), 3 weeks (T3) and 6 weeks (T4). BMI, habits, SF-12 questionnaire, VAS at rest (VASs), after defecation (VASd), and after anorectal digital examination (VASe), bleeding and thrombosis, time to surgical wound healing and autonomy were evaluated.

resultsIn the mesoglycan group, post-operative thrombosis was significantly reduced at T2 (p < 0.05) and T3 (p < 0.005), and all patients experienced less post-operative pain at each time point (p < 0.001 except for VASe T4 p = 0.003). There were no significant differences between the two groups regarding the time to surgical wound healing or post-operative bleeding. There was an early recovery of autonomy in the mesoglycan group in all three follow-up periods (T2 p = 0.016; T3 p = 0.002; T4 p = 0.007).

conclusionsThe use of mesoglycan led to a significant reduction in post-operative thrombosis and pain with consequent early resumption of autonomy. Trial registration NCT04481698-Mesoglycan for Pain Control After Open Excisional HAEMOrrhoidectomy (MeHAEMO) https://clinicaltrials.gov/ct2/show/NCT04481698?term=Mesoglycan+for+Pain+Control+After+Open+Excisional+HAEMOrrhoidectomy+%28MeHAEMO%29&draw=2&rank=1.

Indexed as

HemorrhoidectomyHemorrhoidsPostoperative PainThrombosisAdultAgedAged, 80 and overFemaleFibrinolytic AgentsGlycosaminoglycansHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeYoung AdultFibrinolytic AgentsGlycosaminoglycansmesoglycanHaemorrhoidal diseaseMesoglycanMucocutaneous bridgesOpen excisional haemorrhoidectomyPost-operative painThrombosis

Identifiers

PMID33092570
PMCPMC7583301
OpenAlexW3094264640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.