ArticleCirculation research2021
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca
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Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed, 74 citations in OpenAlex.
- Local calcium dynamics and signalling in cardiomyocytes.Nature reviews. Cardiology · 2026Review
- Super-Resolution 3D Imaging Reveals Disarray of Dyadic Calcium Ion Channels in Failing Hearts Expressing Low Thyroid Hormone Function.International journal of molecular sciences · 2026Article
- JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes.JACC. Basic to translational science · 2026Article
- Revisiting the Genetics of Hypertrophic Cardiomyopathy: From Sarcomeres to Polygenic Modulation and Clinical Translation.Journal of clinical medicine · 2026Review
- Cardiac Cell Remodeling in Obesity and Diabetes.Handbook of experimental pharmacology · 2026Review
- Nanoscale architecture and dynamics of CaJournal of molecular and cellular cardiology plus · 2025Article
- Metabolic-Electrophysiological Coupling in Heart Failure: from Bidirectional Decoupling to Therapeutic Recoupling.Current heart failure reports · 2025Review
- Nonstructural Roles of Junctophilin-2 in the Heart.JACC. Basic to translational science · 2025Review
- Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction.Circulation · 2025Article
- Role of Dyadic Proteins in Proper Heart Function and Disease.International journal of molecular sciences · 2025Review
- The potassium channel KNature communications · 2025Article
- CaInflammation and regeneration · 2025Review
- Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2.Stem cell research & therapy · 2025Article
- Preventing Site-Specific Calpain Proteolysis of Junctophilin-2 Protects Against Stress-Induced Excitation-Contraction Uncoupling and Heart Failure Development.Circulation · 2025Article
- Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis.JCI insight · 2025Article
- Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency.The Journal of general physiology · 2025Article
- The Low Tumorigenic Risk and Subtypes of Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells.Current stem cell research & therapy · 2025Article
- Nanoscale organization of cardiac calcium channels is dependent on thyroid hormone status.American journal of physiology. Heart and circulatory physiology · 2024Article
- Quantitative 3D electron microscopy characterization of mitochondrial structure, mitophagy, and organelle interactions in murine atrial fibrillation.Journal of structural biology · 2024Article
- Augmenting workload drives T-tubule assembly in developing cardiomyocytes.The Journal of physiology · 2024Article
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Authors and funding
24 authors at 7 institutions in 5 countries.
Polina GrossDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Jaslyn JohnsonDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Carlos M RomeroDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Deborah M EatonDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Claire PouletNIHR Imperial Biomedical Research Centre, National Heart and Lung Institute, Imperial College London, London, United Kingdom (C.P., J.S.-A., C.L., J.G.).
Jose Sanchez-AlonsoNIHR Imperial Biomedical Research Centre, National Heart and Lung Institute, Imperial College London, London, United Kingdom (C.P., J.S.-A., C.L., J.G.).
Carla LucarelliNIHR Imperial Biomedical Research Centre, National Heart and Lung Institute, Imperial College London, London, United Kingdom (C.P., J.S.-A., C.L., J.G.).
Jean RossBioimaging Center Research, Delaware Biotechnology Institute, Newark, DE (J.R.).
Andrew A GibbDepartment of Pharmacology, Center for Translational Medicine (A.A.G., J.F.G., J.L., J.E.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Joanne F GarbinciusDepartment of Pharmacology, Center for Translational Medicine (A.A.G., J.F.G., J.L., J.E.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Jonathan LambertDepartment of Pharmacology, Center for Translational Medicine (A.A.G., J.F.G., J.L., J.E.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Erdem VarolDepartment of Statistics, Center for Theoretical Neuroscience, Columbia University, New York, NY (E.V.).
Yijun YangDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Markus WallnerDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Eric A FeldsottDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Hajime KuboDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Remus M BerrettaDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Daohai YuDepartment of Clinical Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (D.Y.).
Victor RizzoDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
John ElrodDepartment of Pharmacology, Center for Translational Medicine (A.A.G., J.F.G., J.L., J.E.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Abdelkarim SabriDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Julia GorelikNIHR Imperial Biomedical Research Centre, National Heart and Lung Institute, Imperial College London, London, United Kingdom (C.P., J.S.-A., C.L., J.G.).
Xiongwen ChenDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Steven R HouserDepartment of Physiology, Cardiovascular Research Center (P.G., J.J., C.M.R., D.M.E., Y.Y., M.W., E.A.F., H.K., R.M.B., V.R., A.S., X.C., S.R.H.), Lewis Katz Temple University School of Medicine, Philadelphia, PA.
Temple University · USNIHR Imperial Biomedical Research Centre · GBCenter for Theoretical Physics · PLFraunhofer USA Center for Molecular Biotechnology · USLung Institute · USMedical University of Graz · ATUniversity of Verona · IT
Funding
Targeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI TILLEY, DOUGLAS · 2020 to 2024
$11.4MIntegrative Cardiovascular PathophysiologyT32HL091804 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2008 to 2024
$4.5MDeacetylase-Dependent Control of Diastolic Dysfunction and HFpEFR01HL147558 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HOUSER, STEVEN R, MCKINSEY, TIMOTHY · 2019 to 2022
$3.1MMolecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0MMitochondria and metabolism in neurodegenerationRF1NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2021 to 2021
$2.3MTargeting Cbl for Cardiac Repair Post-Myocardial InfarctionR01HL145177 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI SABRI, ABDELKARIM · 2019 to 2022
$2.0MProtein activated Receptor-4 in Cardiac Rupture after Myocardial InfarctionR01HL139889 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI SABRI, ABDELKARIM · 2018 to 2021
$1.9MNovel Molecular Mechanisms of Programmed NecrosisR01HL136954 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2017 to 2020
$1.6MMetabolic control of cellular differentiation and the fibrotic responseF32HL145914 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GIBB, ANDREW A · 2019 to 2021
$194kBritish Heart Foundation RG/17/13/33173NHLBI NIH HHS F32 HL145914NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL136954NHLBI NIH HHS R01 HL139889NHLBI NIH HHS R01 HL142271NHLBI NIH HHS R01 HL145177NHLBI NIH HHS R01 HL147558NHLBI NIH HHS T32 HL091804NINDS NIH HHS RF1 NS121379
Abstract
rationaleCa
objectiveTo determine if the joining region in JPH2 recruits LTCCs to T-tubules through direct molecular interaction in cardiomyocytes to enable efficient CICR. METHODS AND
resultsModified abundance of JPH2 and redistribution of LTCC were studied in left ventricular hypertrophy in vivo and in cultured adult feline and rat ventricular myocytes. Protein-protein interaction studies showed that the joining region in JPH2 interacts with LTCC-α1C subunit and causes LTCCs distribution to the dyads, where they colocalize with RyRs. A JPH2 with induced mutations in the joining region (mut
conclusionsThe interaction between LTCC and the joining region in JPH2 facilitates dyad assembly and maintains normal CICR in cardiomyocytes.
Indexed as
Calcium SignalingAnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium Channels, L-TypeCatsCells, CulturedDisease Models, AnimalExcitation Contraction CouplingHumansHypertrophy, Left VentricularKineticsMaleMembrane ProteinsMitochondria, HeartMuscle ProteinsCACNA1C protein, humanCacna1c protein, ratCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium Channels, L-TypeJPH2 protein, humanjunctophilinMembrane ProteinsMuscle ProteinsRyanodine Receptor Calcium Release Channelcalcium channelsheart failurejunctophilin
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