Evidence map›Paper›PMID 33092459›Full record

ArticleEpigenetics

DNA methylation biomarker selected by an ensemble machine learning approach predicts mortality risk in an HIV-positive veteran population.

Chang Shu, Amy C Justice, Xinyu Zhang, Vincent C Marconi, Dana B Hancock, Eric O Johnson, Ke Xu

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Epigenetic associations with kidney disease in individuals of African ancestry with APOL1 high-risk genotypes and HIV.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  5. Article
  6. Methods in DNA methylation array dataset analysis: A review.Computational and structural biotechnology journal · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Epigenetic Age Acceleration Markers Are Associated With Physiologic Frailty and All-Cause Mortality in People With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chang ShuDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3730-5102
Amy C JusticeConnecticut Veteran Healthcare System, West Haven, CT, USA.
Xinyu ZhangDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Vincent C MarconiDivision of Infectious Disease, Emory University School of Medicine, Atlanta, GA, USA.
Dana B HancockGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Eric O JohnsonGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Ke XuDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Yale University · USRTI International · USEmory University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Enhancing Discovery of HIV Host Genetics using Drug Abuse and other InteractionsR01DA038632 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JOHNSON, ERIC OTTO · 2014 to 2018
$3.7M
Feature selection of DNA methylation biosignatures for neuropathy with comorbid drug abuse in the setting of HIV infectionR01DA047820 · NIDA · YALE UNIVERSITY · PI AOUIZERAT, BRADLEY E, XU, KE · 2018 to 2022
$2.9M
Defining the impact of injection drug use on antiretroviral therapy and HIV treatment outcomes: an (epi)genomic approachR01DA047063 · NIDA · YALE UNIVERSITY · PI AOUIZERAT, BRADLEY E, XU, KE · 2018 to 2022
$2.4M
Methylome-wide and mQTL analysis of HIV progression in the context of cocaine useR01DA042691 · NIDA · YALE UNIVERSITY · PI XU, KE · 2016 to 2019
$1.6M
Genome-wide DNA methylation in HIV infected drug usersR03DA039745 · NIDA · YALE UNIVERSITY · PI XU, KE · 2015 to 2016
$260k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA038632NIDA NIH HHS R01 DA042691NIDA NIH HHS R01 DA047063NIDA NIH HHS R01 DA047820NIDA NIH HHS R03 DA039745
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HIV InfectionsVeteransBiomarkersCohort StudiesDNA MethylationHumansMachine LearningBiomarkersDNA methylationHIVmachine learning predictionmortality risk

Identifiers

PMID33092459
PMCPMC8216205
OpenAlexW3093735861

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.