Evidence map›Paper›PMID 33092440›Full record

ReviewJournal of the American Heart Association2020

Transatlantic Lipid Guideline Divergence: Same Data But Different Interpretations.

Carl E Orringer, Lale Tokgozoglu, Kevin C Maki, Kausik K Ray, Joseph J Saseen, Alberico L Catapano

Open access · goldAbstract readReview
In one paragraph

Review in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. CT coronary angiography in the lipid clinic: a pilot study and lipidologist survey.The international journal of cardiovascular imaging · 2025
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Carl E OrringerDepartment of Medicine Cardiovascular Division University of Miami Miller School of Medicine Miami FL.
Lale TokgozogluDepartment of Cardiology Hacettepe University Ankara Turkey.
Kevin C MakiDepartment of Applied Health Science Indiana University School of Public Health Bloomington IN.
Kausik K RayImperial Centre for Cardiovascular Disease Prevention Department of Primary Care and Public Health Imperial College London United Kingdom.
Joseph J SaseenDepartments of Clinical Pharmacy and Family Medicine Schools of Pharmacy and Medicine University of Colorado Anschutz Medical Campus Aurora CO.
Alberico L CatapanoDepartment of Pharmacological and Biomolecular Sciences University of Milan Italy.
Hacettepe University · TRImperial College London · GBIndiana University Bloomington · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Miami · USUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite consensus that excessive circulating concentrations of apoB-lipoproteins is a key driver for the atherosclerotic process and that treatments that low-density lipoprotein cholesterol lowering by up-regulation of low-density lipoprotein cholesterol receptor expression reduces that risk, divergent viewpoints on interpretation of study data have resulted in substantial differences in European and American lipid guideline recommendations. This article explores those differences and highlights the importance of understanding guideline-based lipid management to improve patient care and reduce the risk of clinical atherosclerotic cardiovascular disease.

Indexed as

Cardiovascular DiseasesEuropeHumansHypolipidemic AgentsLipidsPractice Guidelines as TopicRisk FactorsUnited StatesHypolipidemic AgentsLipidsguidelinerisk assessmenttherapy

Identifiers

PMID33092440
PMCPMC7763403
OpenAlexW3093504303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.