Evidence map›Paper›PMID 33092407›Full record

ArticleASN neuro

Astrocyte-Selective Volume Increase in Elevated Extracellular Potassium Conditions Is Mediated by the Na

Erin Walch, Thomas R Murphy, Nicholas Cuvelier, Murad Aldoghmi, Cristine Morozova, Jordan Donohue, Gaby Young, Anuja Samant, Stacy Garcia, Camila Alvarez and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Channels and Transporters in Ischemic Brain Edema.Journal of inflammation research · 2025
    Review
  9. Article
  10. Astrocyte β-Adrenergic Receptor Activity Regulates NMDA Receptor Signaling of Medial Prefrontal Cortex Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. The Glymphatic System: A Novel Component of Fundamental Neurobiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Erin WalchDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, United States.ORCID 0000-0002-7809-9632
Thomas R MurphyDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.ORCID 0000-0002-2168-0602
Nicholas CuvelierDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Murad AldoghmiDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Cristine MorozovaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Jordan DonohueDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.ORCID 0000-0003-2997-5525
Gaby YoungDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Anuja SamantDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Stacy GarciaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Camila AlvarezDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Alex BilasDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
David DavilaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Devin K BinderDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, United States.
Todd A FiaccoCenter for Glial-Neuronal Interactions, University of California, Riverside, Riverside, United States.ORCID 0000-0003-1927-5349
University of California, Riverside · US

Funding

Astrocyte volume-regulated control of neuronal excitabilityR01NS082570 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BINDER, DEVIN K, FIACCO, TODD A · 2013 to 2017
$1.7M
A new combinatorial strategy to selectively manipulate reactive astrocytes in diseaseR21NS109918 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI FIACCO, TODD A, RICCOMAGNO, MARTIN MIGUEL · 2019 to 2020
$401k
NINDS NIH HHS R01 NS082570NINDS NIH HHS R21 NS109918
6 · The paper itself

Abstract

Astrocytes and neurons have been shown to swell across a variety of different conditions, including increases in extracellular potassium concentration (^[K

Indexed as

Cell SizeAnimalsAquaporin 4AstrocytesExtracellular SpaceHippocampusMiceMice, Inbred C57BLMice, TransgenicOrgan Culture TechniquesPotassiumSodium-Potassium-Exchanging ATPaseAqp4 protein, mouseAquaporin 4PotassiumSodium-Potassium-Exchanging ATPasecell swellingcellular edemaextracellular spaceK+ bufferingKir4.1NBCe1NKCC1sodium-potassium pumpvolume regulation

Identifiers

PMID33092407
PMCPMC7586494
OpenAlexW3094186027

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.