ReviewPathogens (Basel, Switzerland)2020
Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health.
Review in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of hepatitis E virus in swine in China: a systematic review with meta-analysis (2004-2023).Frontiers in veterinary science · 2024Pooled it
- Hepatitis E Virus in the Iberian Peninsula: A Systematic Review.Food and environmental virology · 2023Pooled it
- Systematic review of global hepatitis E outbreaks to inform response and coordination initiatives.BMC public health · 2023Pooled it
- Hepatitis E virus and renal injury: A review of pathogenesis, pathology, and clinical management.Infectious medicine · 2026Review
- Global Temporal Trends and Projections of Acute Hepatitis E Epidemiology for Adults 65 Years and Older from 1990 to 2021: Global Burden of Disease 2021 Based Study.Tropical medicine and infectious disease · 2026Article
- Hepatitis E Virus Exposure Across Multiple Host Species in a Shared Ecosystem in Argentina.Veterinary sciences · 2026Article
- Interactions between extracellular vesicles and viruses: lessons learned across species and kingdoms.FEMS microbiology reviews · 2026Review
- Hepatitis E virus (HEV) as an emerging challenge in Poland: a narrative review of epidemiological and clinical data.Archives of medical science : AMS · 2026Article
- Hepatitis E Virus (HEV) Infection Among Pigs in Poland: An Assessment of the Prevalence on Commercial Swine Farms.Transboundary and emerging diseases · 2026Article
- Performance of Elecsys Anti-HEV IgG and IgM Assays for the Detection of Acute, Recent or Past Hepatitis E Virus Infection.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- No evidence of hepatitis E virus-associated central nervous system infections in a Vietnamese multicenter cohort.IJID regions · 2025Article
- Serological and molecular characterization of hepatitis E virus and co-infections during the 2014 Biratnagar outbreak in Nepal.BMC infectious diseases · 2025Article
- High Seroprevalence of Hepatitis E Virus Among Patients With Hepatitis B and Those With Hepatitis of Unknown Etiology in Central Vietnam.Open forum infectious diseases · 2025Article
- Review
- Pathological Characteristics of Pregnant Tree Shrews Infected by Zoonotic Hepatitis E Virus Genotype and the Effect of Estrogen on Virus Replication.Veterinary sciences · 2025Article
- Rapid visual detection of hepatitis E virus combining reverse transcription recombinase-aided amplification with lateral flow dipstick and real-time fluorescence.Journal of clinical microbiology · 2025Article
- Serological and Molecular Survey of Hepatitis E Virus in Small Ruminants from Central Portugal.Food and environmental virology · 2024Article
- Hepatitis E virus in wild and domestic rabbits from Portugal: a combined molecular and longitudinal serological study.Veterinary research communications · 2024Article
- Evaluation of hepatitis E virus RNA persistence in experimentally contaminated cured pork liver sausages.Italian journal of food safety · 2024Article
- Hepatitis E outbreak in the health district of Bocaranga-Koui, Central African Republic, 2018-2019.BMC infectious diseases · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis globally. Although infecting over 20 million people annually in endemic regions, with major outbreaks described since the 1950s, hepatitis E remains an underestimated disease. This review gives a current view of the global circulation and epidemiology of this emerging virus. The history of HEV, from the first reported enteric non-A non-B hepatitis outbreaks, to the discovery of the viral agent and the molecular characterization of the different human pathogenic genotypes, is discussed. Furthermore, the current state of research regarding the virology of HEV is critically assessed, and the challenges towards prevention and diagnosis, as well as clinical risks of the disease described. Together, these points aim to underline the significant impact of hepatitis E on global health and the need for further in-depth research to better understand the pathophysiology and its role in the complex disease manifestations of HEV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.