Evidence map›Paper›PMID 33092305›Full record

ArticlePathogens (Basel, Switzerland)2020

Ursolic Acid Potentializes Conventional Therapy in Experimental Leishmaniasis.

Jéssica Adriana Jesus, Thays Nicolli Fragoso da Silva, Eduardo Seiji Yamamoto, João Henrique G Lago, Márcia Dalastra Laurenti, Luiz Felipe Domingues Passero

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Article
  2. Review
  3. High Selectivity of 8-Hydroxyquinoline onPharmaceuticals (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Leishmanicidal Activity and Ultrastructural Changes of Maslinic Acid Isolated fromEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jéssica Adriana JesusLaboratory of Pathology of Infectious Diseases (LIM50), Department of Pathology, Medical School of São Paulo University, Av. Dr. Arnaldo, 455, São Paulo, SP 01246-903, Brazil.ORCID 0000-0002-7212-5094
Thays Nicolli Fragoso da SilvaLaboratory of Pathology of Infectious Diseases (LIM50), Department of Pathology, Medical School of São Paulo University, Av. Dr. Arnaldo, 455, São Paulo, SP 01246-903, Brazil.
Eduardo Seiji YamamotoLaboratory of Pathology of Infectious Diseases (LIM50), Department of Pathology, Medical School of São Paulo University, Av. Dr. Arnaldo, 455, São Paulo, SP 01246-903, Brazil.
João Henrique G LagoCenter of Natural and Human Sciences, Federal University of ABC (UFABC), Avenida dos Estados 5001, Santo André, SP 09210-580, Brazil.ORCID 0000-0002-1193-8374
Márcia Dalastra LaurentiLaboratory of Pathology of Infectious Diseases (LIM50), Department of Pathology, Medical School of São Paulo University, Av. Dr. Arnaldo, 455, São Paulo, SP 01246-903, Brazil.ORCID 0000-0002-1080-2440
Luiz Felipe Domingues PasseroInstitute of Biosciences, São Paulo State University (UNESP), Praça Infante Dom Henrique, s/n, São Vicente, SP 11330-900, Brazil.
Universidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal do ABC · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/00468-0
6 · The paper itself

Abstract

Ursolic acid (UA) is a triterpene with a broad array of pharmacological activities. In leishmaniasis, UA killed different species of parasites, and it was active in the experimental model of cutaneous and visceral leishmaniasis. Thus, the objective of this work was to study the therapeutic efficacy of the conventional drugs amphotericin B (AmB) or glucantime (Glu) combined with UA in experimental visceral and cutaneous leishmaniasis, respectively.

Indexed as

amphotericin Bcutaneous leishmaniasisglucantimeleishmaniasistherapyvisceral leishmaniasis

Identifiers

PMID33092305
PMCPMC7589377
OpenAlexW3094262238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.