Evidence map›Paper›PMID 33092303›Full record

ArticleInternational journal of molecular sciences2020

Structural and Functional Brain Abnormalities in Mouse Models of Lafora Disease.

Daniel F Burgos, Lorena Cussó, Gentzane Sánchez-Elexpuru, Daniel Calle, Max Bautista Perpinyà, Manuel Desco, José M Serratosa, Marina P Sánchez

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Polyglucosan body disease in an aged chimpanzee (Pan troglodytes).Neuropathology : official journal of the Japanese Society of Neuropathology · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Daniel F BurgosLaboratory of Neurology, Fundación Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, Spain.ORCID 0000-0002-1579-9770
Lorena CussóDepartamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, 28911 Madrid, Spain.
Gentzane Sánchez-ElexpuruLaboratory of Neurology, Fundación Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, Spain.
Daniel CalleInstituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain.
Max Bautista PerpinyàLaboratory of Neurology, Fundación Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, Spain.
Manuel DescoDepartamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, 28911 Madrid, Spain.ORCID 0000-0003-0989-3231
José M SerratosaLaboratory of Neurology, Fundación Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, Spain.
Marina P SánchezLaboratory of Neurology, Fundación Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Autónoma University, 28040 Madrid, Spain.ORCID 0000-0001-6785-7680
Centre for Biomedical Network Research on Rare Diseases · ESSpanish National Centre for Cardiovascular Research · ESUniversity of Cambridge · GB

Funding

Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021
$9.0M
Comunidad de Madrid S2017/BMD-3867 RENIM-CMMinisterio de Economía, Industria y Competitividad, Gobierno de España Rti2018-095784b-100SAFMinisterio de Economía, Industria y Competitividad, Gobierno de España SAF2014-59594-RNINDS NIH HHS P01NS097197Severo Ochoa Center of Excellence SEV-2015-0505
6 · The paper itself

Abstract

Mutations in the

Indexed as

Disease Models, AnimalAnimalsAtrophyBasal GangliaBrainBrain DiseasesCerebellumCerebral CortexGlucoseHippocampusHumansLafora DiseaseMagnetic Resonance ImagingMice, KnockoutMutationPositron-Emission TomographyEpm2a protein, mouseGlucoseNHLRC1 protein, mouseProtein Tyrosine Phosphatases, Non-ReceptorUbiquitin-Protein Ligases1H-HRMAS MRSbrain metabolitesFDG PETLafora diseasemouse modelsMRIvolumetry

Identifiers

PMID33092303
PMCPMC7589150
OpenAlexW3094574868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.