Evidence map›Paper›PMID 33092191›Full record

ArticleInternational journal of molecular sciences2020

Saliva microRNA Biomarkers of Cumulative Concussion.

Steven D Hicks, Robert P Olympia, Cayce Onks, Raymond Y Kim, Kevin J Zhen, Gregory Fedorchak, Samantha DeVita, Aakanksha Rangnekar, Matthew Heller, Hallie Zwibel and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
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  9. Review
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  12. Article
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  14. Observational
  15. Sample-to-answer salivary miRNA testing: New frontiers in point-of-care diagnostic technologies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Steven D HicksDepartment of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-9579-6798
Robert P OlympiaDepartment of Emergency Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.
Cayce OnksDepartment of Family Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.
Raymond Y KimDepartment of Orthopedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0003-4229-904X
Kevin J ZhenDepartment of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA.
Gregory FedorchakQuadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA.ORCID 0000-0002-0772-6053
Samantha DeVitaQuadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA.ORCID 0000-0002-4843-7709
Aakanksha RangnekarQuadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA.
Matthew HellerDepartment of Family Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA.
Hallie ZwibelDepartment of Family Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA.
Chuck MonteithDepartment of Athletic Training, Colgate University, Hamilton, NY 13346, USA.ORCID 0000-0001-8457-9184
Zofia GagnonSchool of Science, Marist College, Poughkeepsie, NY 12601, USA.
Callan D McLoughlinSchool of Science, Marist College, Poughkeepsie, NY 12601, USA.
Jason RandallSchool of Science, Marist College, Poughkeepsie, NY 12601, USA.
Miguel MadeiraSchool of Science, Marist College, Poughkeepsie, NY 12601, USA.ORCID 0000-0001-9771-0727
Thomas R CampbellSchool of Rehabilitation Sciences, Old Dominion University, Norfolk, VA 23529, USA.
Elise FenglerDepartment of Exercise Science, Syracuse University, Syracuse, NY 13210, USA.
Michael N DretschUS Army Medical Research Directorate-West, Walter Reed Army Institute of Research, Joint Base Lewis-McChord, WA 98433, USA.
Christopher NevilleDepartment of PT Education, Orthopedics, and Neuroscience, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Frank A MiddletonDepartment of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent concussions increase risk for persistent post-concussion symptoms, and may lead to chronic neurocognitive deficits. Little is known about the molecular pathways that contribute to persistent concussion symptoms. We hypothesized that salivary measurement of microribonucleic acids (miRNAs), a class of epitranscriptional molecules implicated in concussion pathophysiology, would provide insights about the molecular cascade resulting from recurrent concussions. This hypothesis was tested in a case-control study involving 13 former professional football athletes with a history of recurrent concussion, and 18 age/sex-matched peers. Molecules of interest were further validated in a cross-sectional study of 310 younger individuals with a history of no concussion (

Indexed as

AdolescentAdultAgedAged, 80 and overAthletesBiomarkersBrain ConcussionCase-Control StudiesChildCross-Sectional StudiesFootballHumansMaleMicroRNAsMiddle AgedSalivaBiomarkersMicroRNAsMIRN28 microRNA, humanMIRN339 microRNA, humanbiomarkermicroRNAmild traumatic brain injurysalivasports-related concussion

Identifiers

PMID33092191
PMCPMC7589940

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.