Evidence map›Paper›PMID 33091741›Full record

ArticleMedical image analysis2021

Joint prediction and time estimation of COVID-19 developing severe symptoms using chest CT scan.

Xiaofeng Zhu, Bin Song, Feng Shi, Yanbo Chen, Rongyao Hu, Jiangzhang Gan, Wenhai Zhang, Man Li, Liye Wang, Yaozong Gao and 2 more

Abstract read
In one paragraph

Article in Medical image analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. DenResCov-19: A deep transfer learning network for robust automatic classification of COVID-19, pneumonia, and tuberculosis from X-rays.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2021
    Article
  16. Article
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  18. Review
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  20. Circulating Calprotectin as a Biomarker of COVID-19 Severity.Expert review of clinical immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaofeng ZhuCenter for Future Media and school of computer science and technology, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: seanzhuxf@gmail.com.
Bin SongDepartment of Radiology, Sichuan University West China Hospital, Chengdu 610041, China. Electronic address: anicesong@vip.sina.com.
Feng ShiDepartment of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai 200232, China.
Yanbo ChenDepartment of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai 200232, China.
Rongyao HuCenter for Future Media and school of computer science and technology, University of Electronic Science and Technology of China, Chengdu 611731, China; School of Natural and Computational Sciences, Massey University Auckland, Auckland 0745, New Zealand.
Jiangzhang GanCenter for Future Media and school of computer science and technology, University of Electronic Science and Technology of China, Chengdu 611731, China; School of Natural and Computational Sciences, Massey University Auckland, Auckland 0745, New Zealand.
Wenhai ZhangDepartment of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai 200232, China.
Man LiDepartment of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai 200232, China.
Liye WangDepartment of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai 200232, China.
Yaozong GaoDepartment of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai 200232, China.
Fei ShanDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China. Electronic address: shanfei@shphc.org.cn.
Dinggang ShenDepartment of Research and Development, Shanghai United Imaging Intelligence Co., Ltd., Shanghai 200232, China; School of Biomedical Engineering, ShanghaiTech University, Shanghai 201210, China; Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea. Electronic address: dinggang.shen@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the rapidly worldwide spread of Coronavirus disease (COVID-19), it is of great importance to conduct early diagnosis of COVID-19 and predict the conversion time that patients possibly convert to the severe stage, for designing effective treatment plans and reducing the clinicians' workloads. In this study, we propose a joint classification and regression method to determine whether the patient would develop severe symptoms in the later time formulated as a classification task, and if yes, the conversion time will be predicted formulated as a classification task. To do this, the proposed method takes into account 1) the weight for each sample to reduce the outliers' influence and explore the problem of imbalance classification, and 2) the weight for each feature via a sparsity regularization term to remove the redundant features of the high-dimensional data and learn the shared information across two tasks, i.e., the classification and the regression. To our knowledge, this study is the first work to jointly predict the disease progression and the conversion time, which could help clinicians to deal with the potential severe cases in time or even save the patients' lives. Experimental analysis was conducted on a real data set from two hospitals with 408 chest computed tomography (CT) scans. Results show that our method achieves the best classification (e.g., 85.91% of accuracy) and regression (e.g., 0.462 of the correlation coefficient) performance, compared to all comparison methods. Moreover, our proposed method yields 76.97% of accuracy for predicting the severe cases, 0.524 of the correlation coefficient, and 0.55 days difference for the conversion time.

Indexed as

COVID-19Disease ProgressionFemaleHumansMaleMiddle AgedPneumonia, ViralPredictive Value of TestsRadiographic Image Interpretation, Computer-AssistedRadiography, ThoracicSARS-CoV-2Severity of Illness IndexTime FactorsTomography, X-Ray ComputedCoronavirus diseaseCT Scan dataFeature selectionImbalance classificationSample selection

Identifiers

PMID33091741
PMCPMC7547024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.