ReviewProgress in neurobiology2021
Higher and deeper: Bringing layer fMRI to association cortex.
Review in Progress in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Resolving mesoscale brainstem-prefrontal-striatal pathways underlying decisions upon salient events using submillimeter-resolution fMRI.Nature communications · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- T1234: A distortion-matched structural scan solution to misregistration of high resolution fMRI data.Magnetic resonance in medicine · 2025Article
- Somatostatin-expressing interneurons induce early NO-driven and late specific astrocyte-mediated vasodilation.Nature communications · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.Current topics in behavioral neurosciences · 2025Review
- Detectability and cortical depth dependence of stimulus-driven high-frequency BOLD oscillations in the human primary somatosensory and motor cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Multilayer network analysis across cortical depths in 7-T resting-state fMRI.Network neuroscience (Cambridge, Mass.) · 2025Article
- Multilayer Network Analysis across Cortical Depths in Resting-State 7T fMRI.bioRxiv : the preprint server for biology · 2024Article
- Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Performance of receive head arrays versus ultimate intrinsic SNR at 7 T and 10.5 T.Magnetic resonance in medicine · 2024Article
- Exploring methodological frontiers in laminar fMRI.Psychoradiology · 2024Review
- Acquisition and processing methods of whole-brain layer-fMRI VASO and BOLD: The Kenshu dataset.Aperture neuro · 2023Article
- Functional and microstructural plasticity following social and interoceptive mental training.eLife · 2023Article
- Laminar specificity of the auditory perceptual awareness negativity: A biophysical modeling study.PLoS computational biology · 2023Article
- Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Evaluating increases in sensitivity from NORDIC for diverse fMRI acquisition strategies.NeuroImage · 2023Article
- Laminar Specificity of the Auditory Perceptual Awareness Negativity: A Biophysical Modeling Study.bioRxiv : the preprint server for biology · 2023Article
- The confound of hemodynamic response function variability in human resting-state functional MRI studies.Frontiers in neuroscience · 2023Article
- Human electromagnetic and haemodynamic networks systematically converge in unimodal cortex and diverge in transmodal cortex.PLoS biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent advances in fMRI have enabled non-invasive measurements of brain function in awake, behaving humans at unprecedented spatial resolutions, allowing us to separate activity in distinct cortical layers. While most layer fMRI studies to date have focused on primary cortices, we argue that the next big steps forward in our understanding of cognition will come from expanding this technology into higher-order association cortex, to characterize depth-dependent activity during increasingly sophisticated mental processes. We outline phenomena and theories ripe for investigation with layer fMRI, including perception and imagery, selective attention, and predictive coding. We discuss practical and theoretical challenges to cognitive applications of layer fMRI, including localizing regions of interest in the face of substantial anatomical heterogeneity across individuals, designing appropriate task paradigms within the confines of acquisition parameters, and generating hypotheses for higher-order brain regions where the laminar circuitry is less well understood. We consider how applying layer fMRI in association cortex may help inform computational models of brain function as well as shed light on consciousness and mental illness, and issue a call to arms to our fellow methodologists and neuroscientists to bring layer fMRI to this next frontier.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.