ArticleBiophysical journal2020
Manipulation of the Endocochlear Potential Reveals Two Distinct Types of Cochlear Nonlinearity.
Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 37 citations in OpenAlex.
- Association between endolymphatic hydrops severity and audio-vestibular outcomes in Ménière's disease: A systematic review and meta-analysis of correlation coefficients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane.The Journal of general physiology · 2026Article
- Suppression of Low-Frequency Tones in the Organ of Corti Vibrations of the Basal Turn in the Mongolian Gerbil Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The cortilymph wave: Its relation to the traveling wave, auditory-nerve responses, and low-frequency downward glides.Hearing research · 2025Review
- Narrow elliptical motion at the outer hair cell-Deiters' cell junction explains disparate features of uniaxial displacement measurements.Hearing research · 2025Article
- The Reduced Cortilymph Flow Path in the Short-Wave Region Allows Outer Hair Cells to Produce Focused Traveling-Wave Amplification.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Low-side and multitone suppression in the base of the gerbil cochlea.Biophysical journal · 2025Article
- Histopathological change of age-related hearing loss in female advance-aged CBA/CaJ mice.PloS one · 2025Article
- Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography.Hearing research · 2025Review
- Regional differences in cochlear nonlinearity across the basal organ of Corti of gerbil: Regional differences in cochlear nonlinearity.Hearing research · 2024Article
- Advective mass transport along the cochlear coil.AIP conference proceedings · 2024Article
- The spatial buildup of nonlinear compression in the cochlea.Frontiers in cellular neuroscience · 2024Article
- Dabrafenib protects from cisplatin-induced hearing loss in a clinically relevant mouse model.JCI insight · 2023Article
- Compressed sensing on displacement signals measured with optical coherence tomography.Biomedical optics express · 2023Article
- Linear mixed-effect modeling of organ of Corti vibratory tuning curves.Hearing research · 2023Article
- The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Reconstruction of transverse-longitudinal vibrations in the organ of Corti complex via optical coherence tomography.The Journal of the Acoustical Society of America · 2023Article
- The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea.Scientific reports · 2022Article
- Cochlear motion across the reticular lamina implies that it is not a stiff plate.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian hearing organ, the cochlea, contains an active amplifier to boost the vibrational response to low level sounds. Hallmarks of this active process are sharp location-dependent frequency tuning and compressive nonlinearity over a wide stimulus range. The amplifier relies on outer hair cell (OHC)-generated forces driven in part by the endocochlear potential, the ∼+80 mV potential maintained in scala media, generated by the stria vascularis. We transiently eliminated the endocochlear potential in vivo by an intravenous injection of furosemide and measured the vibrations of different layers in the cochlea's organ of Corti using optical coherence tomography. Distortion product otoacoustic emissions were also monitored. After furosemide injection, the vibrations of the basilar membrane lost the best frequency (BF) peak and showed broad tuning similar to a passive cochlea. The intra-organ of Corti vibrations measured in the region of the OHCs lost the BF peak and showed low-pass responses but retained nonlinearity. This strongly suggests that OHC electromotility was operating and being driven by nonlinear OHC current. Thus, although electromotility is presumably necessary to produce a healthy BF peak, the mere presence of electromotility is not sufficient. The BF peak recovered nearly fully within 2 h, along with the recovery of odd-order distortion product otoacoustic emissions. The recovery pattern suggests that physical shifts in operating condition are a critical step in the recovery process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.