ArticleNeuron2020
Opposing Influence of Top-down and Bottom-up Input on Excitatory Layer 2/3 Neurons in Mouse Primary Visual Cortex.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed.
- Laminar architecture of a decision circuit in the mouse orbitofrontal cortex.Nature communications · 2026Article
- Top-down feedback in deep neural networks leads to functional differences during audiovisual integration.eLife · 2026Article
- Intrinsic timing, not temporal prediction, underlies ramping dynamics in visual and parietal cortex during passive behavior.Science advances · 2026Article
- Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects.eLife · 2026Article
- A Dual Prediction Error Populations Model of Schizophrenia Spectrum Disorders: Bridging NMDA Hypofunction and Gain Hyperfunction.Schizophrenia bulletin · 2026Article
- Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection.Science advances · 2026Article
- Spike-based alignment learning solves the weight transport problem.Nature communications · 2026Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026Review
- Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Psychedelics relax predictive processing in the post-acute period by remodeling cortico-cortical feedback circuits.bioRxiv : the preprint server for biology · 2026Article
- A shared predictive architecture in the sensory cortex for statistical and reward-based learning.Current opinion in neurobiology · 2026Review
- Predictive acoustical processing in human cortical layers.Nature communications · 2026Article
- Cell-type-specific parallel pathways in the canonical cortical microcircuit.bioRxiv : the preprint server for biology · 2026Article
- Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function.bioRxiv : the preprint server for biology · 2026Article
- 'Backpropagation and the brain' realized in cortical error neuron microcircuits.PLoS computational biology · 2026Article
- Intrinsic stabilization of synaptic plasticity improves learning and robustness in artificial neural networks.Nature communications · 2026Article
- Desegregation of neuronal predictive processing.Nature communications · 2026Article
- Global error signal guides local optimization in mismatch calculation.Nature communications · 2026Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
33 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Processing in cortical circuits is driven by combinations of cortical and subcortical inputs. These inputs are often conceptually categorized as bottom-up, conveying sensory information, and top-down, conveying contextual information. Using intracellular recordings in mouse primary visual cortex, we measured neuronal responses to visual input, locomotion, and visuomotor mismatches. We show that layer 2/3 (L2/3) neurons compute a difference between top-down motor-related input and bottom-up visual flow input. Most L2/3 neurons responded to visuomotor mismatch with either hyperpolarization or depolarization, and the size of this response was correlated with distinct physiological properties. Consistent with a subtraction of bottom-up and top-down input, visual and motor-related inputs had opposing influence on L2/3 neurons. In infragranular neurons, we found no evidence of a difference computation and responses were consistent with positive integration of visuomotor inputs. Our results provide evidence that L2/3 functions as a bidirectional comparator of top-down and bottom-up input.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.