ArticleBirth defects research2021
Risk factors and time trends for isolated craniosynostosis.
Article in Birth defects research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Genetics versus environment in the pathophysiology of sagittal synostosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- Non-syndromic craniosynostosis: contemporary concepts in biology, diagnosis, and distraction-based operative strategy.Archives of craniofacial surgery · 2026Article
- Comparison of Cranial Vault Remodeling Versus Spring Cranioplasty for Nonsyndromic Unicoronal Craniosynostosis: Analysis of Outcomes.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Article
- Concurrent myelomeningocele and sagittal craniosynostosis: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Orthoptic findings in trigonocephaly patients after completed visual development.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Craniosynostosis in Isfahan, Iran: A Cross-Sectional Study.Journal of maxillofacial and oral surgery · 2023Article
- The Epidemiology of Biliary Atresia: Exploring the Role of Developmental Factors on Birth Prevalence.The Journal of pediatrics · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundWe sought to investigate associations between maternal/infant characteristics and isolated craniosynostosis as well as its subtypes sagittal, metopic, and coronal synostosis, and assess trends in the prevalence of these conditions.
methodsWe identified cases in the Texas Birth Defects Registry from 1999 to 2014. We used Poisson regression to identify associations between maternal/infant characteristics and craniosynostosis. We used joinpoint regression and unadjusted Poisson regression to evaluate temporal trends. Finally, we computed adjusted Poisson models to evaluate whether temporal trends were evident after accounting for changes in the population distributions of maternal/infant characteristics over time.
resultsRelative to all live births in the general population, cases were more frequently male or preterm. Mothers of cases were more frequently non-Hispanic white and more frequently obese. Non-Hispanic black or Hispanic maternal race/ethnicity was associated with a lower prevalence of all craniosynostosis subtypes. Previous live births were associated with sagittal synostosis; residence on the U.S.-Mexico border was associated with sagittal and coronal synostosis. The prevalence of any isolated craniosynostosis increased (average annual percent change estimated from joinpoint regression [AAPC]: 2.9%), as did the prevalences of sagittal (AAPC: 3.3%) and metopic synostosis (AAPC: 5.4%). In crude Poisson models, the same temporal trends were observed, however these were attenuated after adjusting for maternal/infant characteristics.
conclusionsPrevalence of isolated craniosynostosis increased from 1999 to 2014. The largest AAPC was observed for metopic synostosis. Changes in the population distribution of associated maternal/infant characteristics may explain these trends.
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