ArticlePloS one2020
Superficial capillary perfusion on optical coherence tomography angiography differentiates moderate and severe nonproliferative diabetic retinopathy.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Optical coherence tomography angiography analysis methods: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Capillary-Large Vessel Segmentation on OCTA for Predicting Anti-VEGF Treatment Outcomes in Diabetic Macular Edema.Journal of personalized medicine · 2026Article
- Diabetes May Modulate the Association Between Age and Optical Coherence Tomography Angiography Parameters: A Serial, Cross-Sectional Study.Journal of personalized medicine · 2026Article
- Opposing end-node and junction-node remodeling patterns in diabetic patients on optical coherence tomography angiography.Scientific reports · 2026Article
- Multiparametric OCTA Biomarkers for Classifying Mild Diabetic Retinopathy: A Cross-Sectional Evaluation.Translational vision science & technology · 2026Article
- Deep-learning-based optical coherence tomography reconstruction for high-speed and contrast morphology and vasculature imaging.Journal of biomedical optics · 2026Article
- Widefield SS-OCTA-detected retinal vascular changes and their correlation with DME in diabetes.Frontiers in endocrinology · 2026Article
- Construction and verification of a risk prediction model for diabetic retinopathy patients complicated with deep capillary plexus diabetic macular ischaemia.Frontiers in endocrinology · 2026Article
- Automated FAZ segmentation and diabetic retinopathy classification using OCTA images.BMC ophthalmology · 2025Article
- The Impact of Hypertension on Macular Perfusion in Patients With Referable Diabetic Retinopathy: An OCTA Analysis.Translational vision science & technology · 2025Article
- Volumetric Measures of Capillary Nonperfusion on Optical Coherence Tomography Angiography Detect Early Ischemia in Diabetes Without Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Evaluation of optical coherence tomography angiography and pattern and flash electroretinography in diabetes mellitus without retinopathy.Annals of medicine · 2024Article
- Assessing Preclinical Diabetic Retinopathy: The Role of Optical Coherence Tomography Angiography.Cureus · 2024Article
- Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023Review
- Enhanced Deep Learning Model for Classification of Retinal Optical Coherence Tomography Images.Sensors (Basel, Switzerland) · 2023Article
- Perivenular Capillary Rarefaction in Diabetic Retinopathy: Interdevice Characterization and Association to Clinical Staging.Ophthalmology science · 2023Article
- Optical Coherence Tomography Angiography of Volumetric Arteriovenous Relationships in the Healthy Macula and Their Derangement in Disease.Investigative ophthalmology & visual science · 2023Article
- Pre-Ophthalmoscopic Quantitative Biomarkers in Diabetes Mellitus.Translational vision science & technology · 2023Article
- Application of ImageJ in Optical Coherence Tomography Angiography (OCT-A): A Literature Review.Journal of ophthalmology · 2023Review
- Racial differences in quantitative optical coherence tomography angiography findings between older non-diabetics with co-morbidities.PloS one · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo identify objective optical coherence tomography angiography (OCTA) parameters that characterize the spectrum of non-proliferative diabetic retinopathy (NPDR), especially those that distinguish moderate from severe NPDR.
methodsSixty eyes of 60 patients with treatment-naïve NPDR (mild: 21, moderate: 21, severe: 18), 23 eyes with diabetes and no retinopathy, and 24 healthy control eyes were enrolled. OCTA slabs were segmented into superficial (SCP), middle (MCP), and deep capillary plexus (DCP) and thresholded by a new method based on DCP skeletonized vessel length. The foveal avascular zone (FAZ) area, parafoveal vessel density (VD), and adjusted flow index (AFI) from all three capillary layers and the vessel length density (VLD) of the SCP were compared between each severity group, after adjusting for age and image quality.
resultsAll vessel density markers decreased with increasing severity of NPDR. SCP VD and VLD demonstrated significant differences between eyes with diabetes with no retinopathy and mild NPDR (p = 0.001 and p < 0.001, respectively), as well as between moderate vs. severe NPDR (p = 0.004 and p = 0.009, respectively). MCP VD significantly decreased between moderate and severe NPDR (p = 0.01). AFI significantly increased in the SCP and showed a decreasing trend in the MCP and DCP with increasing NPDR severity.
conclusionsChanges in the SCP VD, SCP VLD, and MCP VD can distinguish severe NPDR from lower-risk stages. SCP changes may be more reliable due to their lower susceptibility to noise and projection artifacts. Thresholding OCTA images based on DCP skeletonized vessel length showed less variability in moderate and severe NPDR. Additional studies are warranted to validate this new thresholding method.
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