ArticlePloS one2020
Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus.
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Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Increased CSF volume, altered brain development and emotional reactivity after postnatal Zika virus infection in infant rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques.Nature communications · 2026Article
- Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection.The Lancet. Microbe · 2025Review
- Macaque Models of Prenatal and Postnatal Zika Virus Exposure and Developmental Outcomes.Journal of the Pediatric Infectious Diseases Society · 2025Review
- Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024Review
- Evaluation of registration-based vs. manual segmentation of rhesus macaque brain MRIs.Brain structure & function · 2024Article
- Fetal Zika virus inoculation in macaques revealed control of the fetal viral load during pregnancy.Virology journal · 2024Article
- Protective efficacy of a Zika purified inactivated virus vaccine candidate during pregnancy in marmosets.NPJ vaccines · 2024Article
- Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus.PLoS pathogens · 2023Article
- Control of maternal Zika virus infection during pregnancy is associated with lower antibody titers in a macaque model.Frontiers in immunology · 2023Article
- Early and mid-gestation Zika virus (ZIKV) infection in the olive baboon (Papio anubis) leads to fetal CNS pathology by term gestation.PLoS pathogens · 2022Article
- Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus.PLoS neglected tropical diseases · 2022Article
- Infections at the maternal-fetal interface: an overview of pathogenesis and defence.Nature reviews. Microbiology · 2022Review
- Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity.Viruses · 2021Article
- SARS-CoV2 infects pancreatic beta cells in vivo and induces cellular and subcellular disruptions that reflect beta cell dysfunction.Research square · 2021Article
- Clinical and Preclinical Evidence for Adverse Neurodevelopment after Postnatal Zika Virus Infection.Tropical medicine and infectious disease · 2021Review
- Non-human Primate Models to Investigate Mechanisms of Infection-Associated Fetal and Pediatric Injury, Teratogenesis and Stillbirth.Frontiers in genetics · 2021Review
- Early Embryonic Loss Following Intravaginal Zika Virus Challenge in Rhesus Macaques.Frontiers in immunology · 2021Article
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Authors and funding
44 authors at 5 institutions in 1 country.
Michelle R KoenigDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.
Elaina RazoDepartment of Pediatrics, UW-Madison, Madison, Wisconsin, United States of America.
Ann MitzeyDepartment of Comparative Biosciences, UW-Madison, Madison, Wisconsin, United States of America.
Christina M NewmanDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.
Dawn M DudleyDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.
Meghan E BreitbachDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0001-5974-8353
Matthew R SemlerDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.
Laurel M StewartDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.
Andrea M WeilerWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.
Sierra RybarczykWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.
Kathryn M BachDepartment of Kinesiology, UW-Madison, Madison, Wisconsin, United States of America.
Mariel S MohnsDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.
Heather A SimmonsWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.
Andres MejiaWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.
Michael FritschDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.
Maria DennisDepartment of Pediatrics, Duke University, Durham, North Carolina, United States of America.
Leandro B C TeixeiraDepartment of Pathobiological Sciences, UW-Madison, Madison, Wisconsin, United States of America.
Michele L SchotzkoWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.
T Michael NorkDepartment of Ophthalmology and Visual Sciences, UW-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-0687-373X
Carol A RasmussenDepartment of Ophthalmology and Visual Sciences, UW-Madison, Madison, Wisconsin, United States of America.
Alex KatzDepartment of Ophthalmology and Visual Sciences, UW-Madison, Madison, Wisconsin, United States of America.
Veena NairDepartment of Radiology, UW-Madison, Madison, Wisconsin, United States of America.
Jiancheng HouDepartment of Radiology, UW-Madison, Madison, Wisconsin, United States of America.
Amy HartmanDepartment of Communication Sciences and Disorders, UW-Madison, Madison, Wisconsin, United States of America.
James Ver HoeveDepartment of Ophthalmology and Visual Sciences, UW-Madison, Madison, Wisconsin, United States of America.
Charlene KimDepartment of Ophthalmology and Visual Sciences, UW-Madison, Madison, Wisconsin, United States of America.
Mary L SchneiderDepartment of Kinesiology, UW-Madison, Madison, Wisconsin, United States of America.
Karla AusderauDepartment of Kinesiology, UW-Madison, Madison, Wisconsin, United States of America.
Sarah KohnDepartment of Radiology, UW-Madison, Madison, Wisconsin, United States of America.
Anna S JaegerDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America.
Matthew T AliotaDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America.
Jennifer M HayesWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.
Nancy Schultz-DarkenWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-8436-2820
Jens EickhoffBiostatistics and Medical Informatics, UW-Madison, Madison, Wisconsin, United States of America.
Kathleen M AntonyDepartment of Obstetrics and Gynecology, UW-Madison, Madison, Wisconsin, United States of America.
Kevin NoguchiDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, United States of America.
Xiankun ZengUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America.
Sallie PermarDepartment of Pediatrics, Duke University, Durham, North Carolina, United States of America.
Vivek PrabhakaranDepartment of Radiology, UW-Madison, Madison, Wisconsin, United States of America.
Saverio CapuanoWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.
Thomas C FriedrichWisconsin National Primate Research Center, UW-Madison, Madison, Wisconsin, United States of America.
Thaddeus G GolosDepartment of Comparative Biosciences, UW-Madison, Madison, Wisconsin, United States of America.
David H O'ConnorDepartment of Pathology and Laboratory Medicine, UW-Madison, Madison, Wisconsin, United States of America.
Emma L MohrDepartment of Pediatrics, UW-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0003-0742-305X
University of Wisconsin–Madison · USDuke University · USUniversity of Minnesota · USUnited States Army Medical Research Institute of Infectious Diseases · USWashington University in St. Louis · US
Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MUniversity of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MWUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5MUW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6MZika virus pathophysiology during pregnancyP01AI132132 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$10.2MGBV-C-mediated protection from AIDS in humans and GBV-C/SIV co-infected macaquesR01AI116382 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2015 to 2018
$6.5MAssessing the impact of acquired immunodeficiency on congenital Zika virusR01AI138647 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$3.8MMinnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2MPrevious exposure to dengue as a risk factor for Zika during pregnancyR01AI132563 · NIAID · UNIVERSITY OF MINNESOTA · PI ALIOTA, MATTHEW T · 2018 to 2022
$2.8MGraduate Training in Cellular and Molecular Pathogenesis of Human DiseasesT32GM135119 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Zsuzsanna Fabry · 2020 to 2026
$2.2MGraduate Training In Cellular And Molecular Pathogenesis Of Human DiseasesT32GM081061 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FABRY, ZSUZSANNA · 2010 to 2019
$1.8MDefining maternal and neonatal antibody responses in congenital Zika virus infectionK08AI139341 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MOHR, EMMA L · 2019 to 2023
$1.0MNCATS NIH HHS UL1 TR002373NEI NIH HHS P30 EY016665NIAID NIH HHS K08 AI139341NIAID NIH HHS P01 AI132132NIAID NIH HHS R01 AI116382NIAID NIH HHS R01 AI132563NIAID NIH HHS R01 AI138647NIAID NIH HHS R56 AI132563NIAID NIH HHS T32 AI083196NICHD NIH HHS P50 HD103525NIGMS NIH HHS T32 GM081061NIGMS NIH HHS T32 GM135119NIH HHS P51 OD011106
Abstract
Congenital Zika virus (ZIKV) exposure results in a spectrum of disease ranging from severe birth defects to delayed onset neurodevelopmental deficits. ZIKV-related neuropathogenesis, predictors of birth defects, and neurodevelopmental deficits are not well defined in people. Here we assess the methodological and statistical feasibility of a congenital ZIKV exposure macaque model for identifying infant neurobehavior and brain abnormalities that may underlie neurodevelopmental deficits. We inoculated five pregnant macaques with ZIKV and mock-inoculated one macaque in the first trimester. Following birth, growth, ocular structure/function, brain structure, hearing, histopathology, and neurobehavior were quantitatively assessed during the first week of life. We identified the typical pregnancy outcomes of congenital ZIKV infection, with fetal demise and placental abnormalities. We estimated sample sizes needed to define differences between groups and demonstrated that future studies quantifying brain region volumes, retinal structure, hearing, and visual pathway function require a sample size of 14 animals per group (14 ZIKV, 14 control) to detect statistically significant differences in at least half of the infant exam parameters. Establishing the parameters for future studies of neurodevelopmental outcomes following congenital ZIKV exposure in macaques is essential for robust and rigorous experimental design.
Indexed as
AnimalsAnimals, NewbornFemaleHearing DisordersMacaca mulattaNervous System MalformationsPregnancyPregnancy Complications, InfectiousPregnancy OutcomePrenatal Exposure Delayed EffectsVision DisordersZika VirusZika Virus Infection
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