ArticlePloS one2020
Cats shedding pathogenic Leptospira spp.-An underestimated zoonotic risk?
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Detection of Leptospira in cane toads (Rhinella jimi) from urban and rural Paraíba, Brazil.The Veterinary record · 2026Article
- Review
- Pathogenic Leptospira species identified in dogs and cats during neutering in Thailand.PLoS neglected tropical diseases · 2026Article
- Leptospirosis in Southeast Asia: Investigating Seroprevalence, Transmission Patterns, and Diagnostic Challenges.Tropical medicine and infectious disease · 2026Review
- Seropositivity for PathogenicTropical medicine and infectious disease · 2025Article
- Seroreactivity againstOne health (Amsterdam, Netherlands) · 2024Article
- Grenadian cats as potential reservoir for Leptospira.PLoS neglected tropical diseases · 2024Article
- Infection and re-infection ofVeterinary world · 2024Article
- Feline leptospirosis prevalence worldwide: A systematic review and meta-analysis of diagnostic approaches.Veterinary world · 2024Article
- Seroprevalence of pathogenicFrontiers in veterinary science · 2024Review
- Acute phase proteins and total antioxidant capacity in free-roaming cats infected by pathogenic leptospires.BMC veterinary research · 2023Article
- Evaluation ofJournal of feline medicine and surgery · 2023Article
- Basic Aspects and Epidemiological Studies on Leptospirosis Carried Out in Animals in Chile: A Bibliographic Review.Tropical medicine and infectious disease · 2023Review
- Feline Susceptibility to Leptospirosis and Presence of Immunosuppressive Co-Morbidities: First European Report ofTropical medicine and infectious disease · 2023Article
- Article
- Canine leptospirosis in Canada, test-positive proportion and risk factors (2009 to 2018): A cross-sectional study.PloS one · 2022Article
- Serological and molecular detection of pathogenicEpidemiology and infection · 2021Article
- Updated ACVIM consensus statement on leptospirosis in dogs.Journal of veterinary internal medicineArticle
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shedding of DNA of pathogenic Leptospira spp. has been documented in naturally infected cats in several countries, but urinary shedding of infectious Leptospira spp. has only recently been proven. The climate in Southern Chile is temperate rainy with high annual precipitations which represents ideal preconditions for survival of Leptospira spp., especially during spring and summer. The aims of this study were to investigate shedding of pathogenic Leptospira spp. in outdoor cats in Southern Chile, to perform molecular characterization of isolates growing in culture, and to assess potential risk factors associated with shedding. Urine samples of 231 outdoor cats from rural and urban areas in southern Chile were collected. Urine samples were investigated for pathogenic Leptospira spp. by 4 techniques: qPCR targeting the lipL32 gene, immunomagnetic separation (IMS)-coupled qPCR (IMS-qPCR), direct culture and IMS-coupled culture. Positive urine cultures were additionally confirmed by PCR. Multilocus sequence typing (MLST) was used to molecularly characterize isolates obtained from positive cultures. Overall, 36 urine samples (15.6%, 95% confidence interval (CI) 11.4-20.9) showed positive results. Eighteen (7.8%, 95% CI 4.9-12.1), 30 (13%, 95% CI 9.2-18), 3 (1.3%, 0.3-3.9) and 4 cats (1.7%; 95% CI 0.5-4.5) were positive in qPCR, IMS-qPCR, conventional culture, and IMS-coupled culture, respectively. MLST results of 7 culture-positive cats revealed sequences that could be assigned to sequence type 17 (6 cats) and sequence type 27 (1 cat) corresponding to L. interrogans (Pathogenic Leptospira Subgroup 1). Shedding of pathogenic Leptospira spp. by cats might be an underestimated source of infection for other species including humans. The present study is the first one reporting growth of leptospires from feline urine in culture in naturally infected cats in South-America and characterisation of culture-derived isolates. So far, very few cases of successful attempts to culture leptospires from naturally infected cats are described worldwide.
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