Evidence map›Paper›PMID 33090762›Full record

ArticleACS nano2020

Nanoparticles Yield Increased Drug Uptake and Therapeutic Efficacy upon Sequential Near-Infrared Irradiation.

Dong Luo, Xinning Wang, Ethan Walker, Jing Wang, Sarah Springer, Jason Lou, Gopalakrishnan Ramamurthy, Clemens Burda, James P Basilion

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Applications of AuNanomaterials (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xinning Wang
Ethan Walker
Jing Wang
Sarah Springer
Jason Lou
Gopalakrishnan Ramamurthy
Clemens Burda
James P Basilion
Case Western Reserve University · US

Funding

Theranostic gold nanoparticles for imaged-guided radical prostatectomy and PDT ablationR01EB020353 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI BASILION, JAMES PETER · 2016 to 2019
$2.7M
NIBIB NIH HHS R01 EB020353
6 · The paper itself

Abstract

Nanoparticles offer great opportunities for precision medicine. However, the use of nanoparticles as smart photosensitizers that target tumor biomarkers and are responsive to the tumor microenvironment has yet to be explored. Herein, prostate cancer (PCa)-selective theranostic gold nanoparticles (AuNPs) for precise cancer imaging and therapy are developed. Silicon phthalocyanine, Pc158, was synthesized and deactivated by conjugating it to AuNPs

Indexed as

Metal NanoparticlesNanoparticlesPharmaceutical PreparationsPhotochemotherapyCell Line, TumorGoldHumansMalePhotosensitizing AgentsGoldPharmaceutical PreparationsPhotosensitizing Agentsnanoparticlesphotodynamic therapyprostate cancerPSMAsequential irradiation

Identifiers

PMID33090762
PMCPMC9109620
OpenAlexW3093863246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.