ArticleAging cell2020
Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models.
Open access · goldAbstract read
In one paragraph
Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation.Cells · 2022Pooled it
- Pooled it
- Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026Review
- Retinal proteomics in neurodegeneration: Insights into ocular and brain disorders.Neural regeneration research · 2026Article
- Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuroinflammation in Alzheimer's disease-associated sensory dysfunction: mechanistic links, actionable targets and therapeutic strategies.Frontiers in aging neuroscience · 2026Review
- Exploring Retinal Neurodegeneration in Alzheimer's Disease: A Molecular and Cellular Perspective.Neurotoxicity research · 2025Review
- Article
- Multimodal photoacoustic microscopy and optical coherence tomography ocular biomarker imaging in Alzheimer's disease in mice.Biomedical optics express · 2024Article
- Hyperspectral retinal imaging in Alzheimer's disease and age-related macular degeneration: a review.Acta neuropathologica communications · 2024Review
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages.GeroScience · 2024Review
- Retinal imaging and Alzheimer's disease: a future powered by Artificial Intelligence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Review
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Treatment with glatiramer acetate in APPswe/PS1dE9 mice at an early stage of Alzheimer's disease prior to amyloid-beta deposition delays the disease's pathological development and ameliorates cognitive decline.Frontiers in aging neuroscience · 2024Article
- Potential Retinal Biomarkers in Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Inconsistent Effects of Glatiramer Acetate Treatment in the 5xFAD Mouse Model of Alzheimer's Disease.Pharmaceutics · 2023Article
- The Cleavage-Specific Tau 12A12mAb Exerts an Anti-Amyloidogenic Action by Modulating the Endocytic and Bioenergetic Pathways in Alzheimer's Disease Mouse Model.International journal of molecular sciences · 2023Article
- Amyloid-β targeting immunisation in aged non-human primate (Microcebus murinus).Brain, behavior, and immunity · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Jonah DoustarDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-3029-0067
Altan RentsendorjDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.
Tania TorbatiDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-9409-791X
Giovanna C RegisDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-3606-3882
Dieu-Trang FuchsDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.
Julia SheynDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.
Nazanin MirzaeiDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-5753-5300
Stuart L GrahamDepartment of Clinical Medicine, Macquarie University, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0001-7519-969X
Prediman K ShahOppenheimer Atherosclerosis Research Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-6351-8291
Mitra MastaliDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-9988-092X
Jennifer E Van EykDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-9050-148X
Keith L BlackDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-0546-4934
Vivek K GuptaDepartment of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Mehdi MirzaeiDepartment of Clinical Medicine, Macquarie University, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0001-8727-4984
Yosef KoronyoDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.
Maya Koronyo-HamaouiDepartment of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Research Institute, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-2864-8442
Cedars-Sinai Medical Center · USAustralian Hearing · AUMacquarie University · AUThe University of Sydney · AU
Funding
Alzheimer's Disease Hallmark Pathology and Associated Inflammation in the RetinaR01AG055865 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Maya Koronyo-Hamaoui · 2018 to 2026
$4.9MRetinal Imaging of Alzheimer's Disease PathologyR01AG056478 · NIA · CEDARS-SINAI MEDICAL CENTER · PI KORONYO-HAMAOUI, MAYA · 2017 to 2021
$2.5MAustralian Government's National Collaborative Research Infrastructure SchemeMacquarie UniversityNational Health and Medical Research CouncilNIA NIH HHS R01 AG055865NIA NIH HHS R01AG055865NIA NIH HHS R01 AG056478NIA NIH HHS R01AG056478Petersen FoundationThe Maurice Marciano Family FoundationThe Saban Family FoundationTom Gordon Foundation
Abstract
Despite growing evidence for the characteristic signs of Alzheimer's disease (AD) in the neurosensory retina, our understanding of retina-brain relationships, especially at advanced disease stages and in response to therapy, is lacking. In transgenic models of AD (APP
Indexed as
astrocytes reactivationglutamine synthetasemyeloid cellsneurodegenerative diseaseocular proteinsretinasynaptic preservationvascular amyloidosis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.